Mayo Clinic Laboratory and Pathology Research Roundup: Oct. 9
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The Research Roundup provides an overview of the past week’s research from Mayo Medical Laboratories consultants, including featured abstracts and complete list of published studies and reviews.
Featured Abstract
A Subset of Well-Differentiated Hepatocellular Carcinomas Are Arginase-1 Negative
Hepatocellular carcinoma (HCC) is a common malignancy both in the U.S. and worldwide. Despite the refinement of imaging techniques in at-risk populations, a needle biopsy diagnosis remains an important diagnostic tool for HCC in many cases. Various immunohistochemical markers have been developed to facilitate this diagnosis, such as HepPar-1, glypican-3 and, most recently, arginase-1. Among them, arginase-1 has been shown to have superior sensitivity and specificity than the others. Performance of arginase-1 has been reported to be excellent for diagnosis of well differentiated HCCs, with some tail- off in sensitivity for poorly differentiated tumors. Mayo Clinic researchers' experience has suggested that a subset of well-differentiated HCCs can be negative for arginase-1. They examined 68 consecutive confirmed cases of well-differentiated HCC diagnosed on needle biopsy and found 7 (10%) to be completely negative for arginase-1. This finding is of fundamental clinical importance in view of previous studies that have shown arginase-1 to be always positive in well-differentiated HCC. The review was published in Human Pathology.
Published to PubMed This Week
- Multicenter Validation of Enhancer of Zeste Homolog 2 Expression as an Independent Prognostic Marker in Localized Clear Cell Renal Cell Carcinoma
Journal of Clinical Oncology - Importance of Routine Antihuman/Leukocyte Antibody Monitoring: De Novo Donor Specific Antibodies Are Associated With Rejection and Allograft Vasculopathy After Heart Transplantation
Circulation - Associations Between Cancer Predisposition Testing Panel Genes and Breast Cancer
JAMA Oncology - Diagnosis and Management of Waldenström Macroglobulinemia: Mayo Stratification of Macroglobulinemia and Risk-Adapted Therapy (mSMART) Guidelines 2016
JAMA Oncology - Fructose-1,6-bisphosphatase Inhibits ERK Activation and Bypasses Gemcitabine Resistance in Pancreatic Cancer by Blocking IQGAP1-MAPK Interaction
Cancer Research - Autologous Mesenchymal Stem Cells Increase Cortical Perfusion in Renovascular Disease
Journal of the American Society of Nephrology - Lenalidomide Maintenance Therapy in Previously Treated Chronic Lymphocytic Leukaemia (CONTINUUM): A Randomised, Double-Blind, Placebo-Controlled, Phase 3 Trial
Lancet Haematology - Event-Free Survival at 24 Months Captures Central Nervous System Relapse of Systemic Diffuse Large B-Cell Lymphoma in the Immunochemotherapy Era
British Journal of Haematology - North Central Cancer Treatment Group N0543 (Alliance): A Phase 2 Trial of Pharmacogenetic-Based Dosing of Irinotecan, Oxaliplatin, and Capecitabine as First-Line Therapy for Patients with Advanced Small Bowel Adenocarcinoma
Cancer - Comparison of a Sentinel Lymph Node Mapping Algorithm and Comprehensive Lymphadenectomy in the Detection of Stage IIIC Endometrial Carcinoma at Higher Risk for Nodal Disease
Gynecologic Oncology - Optimizing Test Utilization in the Clinical Microbiology Laboratory: Tools and Opportunities
Journal of Clinical Microbiology - How Do I … Manage the Platelet Transfusion-Refractory Patient?
Transfusion - Heat Stress Induced, Ligand-Independent MET and EGFR Signaling in Hepatocellular Carcinoma
International Journal of Hyperthermia - Genotypic Analysis of Tropheryma Whipplei From Patients with Whipple Disease in the Americas
Journal of Clinical Pathology - The Role of TLR4 Signaling in the Nephrotoxicity of Heme and Heme Proteins
American Journal of Physiology - Renal Physiology - Tenosynovial Giant Cell Tumors of the Temporomandibular Joint and Lateral Skull Base: Review of 11 Cases
Laryngoscope - Real-Time Methylation-Specific Polymerase Chain Reaction for MGMT Promoter Methylation Clinical Testing in Glioblastoma: An Alternative Detection Method for a Heterogeneous Process
American Journal of Clinical Pathology - Novel NR2F1 Variants Likely Disrupt DNA Binding: Molecular Modeling in Two Cases, Review of Published Cases, Genotype-Phenotype Correlation and Phenotypic Expansion of the Bosch-Boonstra-Schaaf Optic Atrophy Syndrome
Cold Spring Harbor Molecular Case Studies - Intrinsic BET Inhibitor Resistance in SPOP-Mutated Prostate Cancer is Mediated by BET Protein Stabilization and AKT-mTORC1 Activation
Nature Medicine
