Mayo Clinic Laboratory and Pathology Research Roundup: Oct. 30
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The Research Roundup provides an overview of the past week’s research from Mayo Medical Laboratories consultants, including featured abstracts and complete list of published studies and reviews.
Featured Abstract
Rates of Hippocampal Atrophy and Presence of Post-Mortem TDP-43 in Patients with Alzheimer's Disease: A Longitudinal Retrospective Study
Post-mortem studies have not identified an association between β-amyloid or tau and rates of hippocampal atrophy in patients with Alzheimer's disease. TAR DNA binding protein 43 (TDP-43) is another protein linked to Alzheimer's disease. Mayo Clinic researchers aimed to investigate whether hippocampal TDP-43 is associated with increased rates of hippocampal atrophy. Researchers did TDP-43 immunohistochemistry and classified individuals as follows: no TDP-43 in the amygdala or hippocampus; TDP-43 restricted to the amygdala; and TDP-43 spreading into the hippocampus. Based on the results, TDP-43 should be considered as a potential factor related to increased rates of hippocampal atrophy in patients with Alzheimer's disease. Given the importance of hippocampal atrophy in Alzheimer's disease, it is imperative that techniques are developed for detection of TDP-43 in vivo. The review was published in The Lancet: Neurology.
Published to PubMed This Week
- Diagnostic Criteria for Chronic Lymphocytic Inflammation with Pontine Perivascular Enhancement Responsive to Steroids (CLIPPERS)
Brain - Accuracy and Safety of the Cytosponge for Assessing Histologic Activity in Eosinophilic Esophagitis: A Two-Center Study
American Journal of Gastroenterology - MAPT Haplotype H1G is Associated with Increased Risk of Dementia with Lewy Bodies
Alzheimer's & Dementia - 2017 Infectious Diseases Society of America Infectious Diarrhea Guidelines: A View From the Clinical Laboratory
Clinical Infectious Diseases - Prevalence of Myeloma Precursor State Monoclonal Gammopathy of Undetermined Significance in 12372 Individuals 10-49 Years Old: A Population-Based Study From the National Health and Nutrition Examination Survey
Blood Cancer Journal - Diffuse Staining for Activated NOTCH1 Correlates With NOTCH1 Mutation Status and Is Associated With Worse Outcome in Adenoid Cystic Carcinoma
American Journal of Surgical Pathology - BRAF V600E Mutations Occur in a Subset of Glomus Tumors, and Are Associated With Malignant Histologic Characteristics
American Journal of Surgical Pathology - Gender and Survival in Essential Thrombocythemia: A Two-Center Study of 1,494 Patients
American Journal of Hematology - Risk Factors and a Prognostic Model for Postsplenectomy Survival in Myelofibrosis
American Journal of Hematology - Contemporary Risk Stratification After Myocardial Infarction in the Community: Performance of Scores and Incremental Value of Soluble Suppression of Tumorigenicity-2
Journal of the American Heart Association - Isolated Acute Terminal Ileitis Without Preexisting Inflammatory Bowel Disease Rarely Progresses to Crohn's Disease
Digestive Diseases and Sciences - Malignant Peripheral Nerve Sheath Tumor in a Patient with BAP1 Tumor Predisposition Syndrome: Case Report
World Neurosurgery - Description of Analytical Method and Clinical Utility of Measuring Serum 7-alpha-hydroxy-4-cholesten-3-one (7aC4) by Mass Spectrometry
Clinical Biochemistry - Real-Time Methylation-Specific Polymerase Chain Reaction for MGMT Promoter Methylation Clinical Testing in Glioblastoma: An Alternative Detection Method for a Heterogeneous Process
American Journal of Clinical Pathology - Cryptogenic Cirrhosis and Sitosterolemia: A Treatable Disease If Identified but Fatal If Missed
Annals of Hepatology
