Mayo Clinic Laboratory and Pathology Research Roundup: Nov. 6

By Kelley Luedke • November 6, 2017

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The Research Roundup provides an overview of the past week’s research from Mayo Medical Laboratories consultants, including featured abstracts and complete list of published studies and reviews.

Featured Abstract

International Assessment of Event-Free Survival at 24 Months and Subsequent Survival in Peripheral T-Cell Lymphoma

Peripheral T-cell lymphomas (PTCLs) have aggressive clinical behavior. Mayo Clinic researchers have previously shown that event-free survival (EFS) at 24 months (EFS24) is a clinically useful end point in diffuse large B-cell lymphoma. Here, researchers assess EFS24 and subsequent overall survival in large, multinational PTCL cohorts. Based on the results, EFS24 stratifies subsequent outcome in PTCL. Patients with PTCL with primary refractory disease or early relapse have extremely poor survival. However, more than one-third of patients with PTCL remain in remission 2 years after diagnosis with encouraging subsequent overall survival, especially in younger patients. These marked differences in outcome suggest that EFS24 has utility for patient counseling, study design, and risk stratification in PTCL. The review was published in the Journal of Clinical Oncology.

Published to PubMed This Week

• Prognostic Significance of ASXL1 Mutation Types and Allele Burden in Myelofibrosis
  Leukemia
• A Prospective Genome-Wide Study of Prostate Cancer Metastases Reveals Association of Wnt Pathway Activation and Increased Cell Cycle Proliferation with Primary Resistance to Abiraterone Acetate-Prednisone
  Annals of Oncology
• Diagnostic Criteria for Chronic Lymphocytic Inflammation with Pontine Perivascular Enhancement Responsive to Steroids (CLIPPERS)
  Brain
• Comparison of Gadolinium Concentrations within Multiple Rat Organs after Intravenous Administration of Linear versus Macrocyclic Gadolinium Chelates
  Radiology
• Gadolinium Deposition in Human Brain Tissues after Contrast-enhanced MR Imaging in Adult Patients without Intracranial Abnormalities
  Radiology
• Loss of BAP1 Expression in Atypical Mesothelial Proliferations Helps to Predict Malignant Mesothelioma
  The American Journal of Surgical Pathology
• Impact of MYD88 Mutation Status in Waldenström Macroglobulinemia
  American Journal of Hematology
• Fatty Acid Synthase (FASN) as a Therapeutic Target in Breast Cancer
  Expert Opinion on Therapeutic Targets
• Characterization of C3 in C3 Glomerulopathy
  Nephrology Dialysis Transplantation
• High-Sensitivity Cardiac Troponin T Improves the Diagnosis of Perioperative MI
  Anesthesia & Analgesia
• Hepatitis E Virus (HEV) Detection and Quantification by a Real-Time Reverse Transcription-PCR Assay Calibrated to the World Health Organization Standard for HEV RNA
  Journal of Clinical Microbiology
• Reply to "Modern Hematology Analyzers Are Very Useful for Diagnosis of Malaria and, Crucially, May Help Avoid Misdiagnosis"
  Journal of Clinical Microbiology
• CD56+ Immune Cell Infiltration and MICA are Decreased in Breast Lobules with Fibrocystic Changes
  Breast Cancer Research and Treatment
• The Contribution of Pain in Determining the Health Status of Cancer Patients with Bone Metastases: A Secondary Analysis of Data from Three Phase III Registration Trials
  European Journal of Pain
• Cardiovascular Phenotype in Smad3 Deficient Mice with Renovascular Hypertension
  PLoS One
• Hermansky-Pudlak Syndrome Subtype 5 (HPS-5) Novel Mutation in a 65 Year-Old with Oculocutaneous Hypopigmentation and Mild Bleeding Diathesis: The Importance of Recognizing a Subtle Phenotype
  Platelets
• Evaluation of Lactate, White Blood Cell Count, Neutrophil Count, Procalcitonin and Immature Granulocyte Count as Biomarkers for Sepsis in Emergency Department Patients
  Clinical Biochemistry
• Undifferentiated Pancreatic Carcinomas Display Enrichment for Frequency and Extent of PD-L1 Expression by Tumor Cells.
  American Journal of Clinical Pathology
• Gene Expression Correlates of Site-Specific Metastasis among Men with Lymph Node Positive Prostate Cancer Treated with Radical Prostatectomy: a Case Series
  Urology
• Therapeutic Plasma Exchange Causing (Not Curing) Hemolysis
  Journal of Clinical Apheresis
• "Chondroblastoma-like" Epithelioid Fibrous Histiocytoma: A Previously Undescribed and Potentially Confusing Variant
  Journal of Cutaneous Pathology

Kelley Luedke

Kelley Luedke is a Marketing Channel Manager at Mayo Clinic Laboratories. She is the principle editor and writer of Insights and leads social media and direct marketing strategy. Kelley has worked at Mayo Clinic since 2013. Outside of work, you can find Kelley running, traveling, playing with her kitty, and exploring new foods.