Mayo Clinic Laboratory and Pathology Research Roundup: Nov. 13

By Kelley Luedke • November 13, 2017

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The Research Roundup provides an overview of the past week’s research from Mayo Medical Laboratories consultants, including featured abstracts and complete list of published studies and reviews.

Featured Abstract

DnaJ Heat Shock Protein Family B Member 9 is a Novel Biomarker for Fibrillary GN

Fibrillary GN (FGN) is a rare primary glomerular disease. Histologic and histochemical features of FGN overlap with those of other glomerular diseases, and no unique histologic biomarkers for diagnosing FGN have been identified. Mayo Clinic researchers analyzed the proteomic content of glomeruli in patient biopsy specimens and detected DnaJ heat shock protein family (Hsp40) member B9 (DNAJB9) as the fourth most abundant protein in FGN glomeruli. Overall, their findings indicate that DNAJB9 is an FGN marker with 100% sensitivity and 100% specificity. The magnitude and specificity of DNAJB9 overabundance in FGN also suggests that this protein has a role in FGN pathogenesis. With this evidence, researchers propose that DNAJB9 is a strong biomarker for rapid diagnosis of FGN in renal biopsy specimens. The review was published in the Journal of the American Society of Nephrology.

Published to PubMed This Week

• Moonlighting Newborn Screening Markers: The Incidental Discovery of a Second-Tier Test for Pompe Disease
  Genetics in Medicine
• Precision Newborn Screening for Lysosomal Disorders
  Genetics in Medicine
• Association Between Obesity and Discordance in Fibrosis Stage Determination by Magnetic Resonance vs Transient Elastography in Patients with Non-alcoholic Liver Disease
  Clinical Gastroenterology and Hepatology
• The Incidence of Primary vs Secondary Focal Segmental Glomerulosclerosis: A Clinicopathologic Study
  Mayo Clinic Proceedings
• Laboratory Services for Managing Thyroid Disease: Different and Common Viewpoints of ATA and AACC Members
  Thyroid
• Practical Approach to the Flattened Duodenal Biopsy
  Surgical Pathology Clinics
• How Shall We Transfuse Hippolyta?
  American Journal of Obstetrics & Gynecology
• Relapse Rates With Surgery Alone in Human Papillomavirus-Related Intermediate- and High-Risk Group Oropharynx Squamous Cell Cancer: A Multi-Institutional Review
  International Journal of Radiation Oncology * Biology * Physics
• Frequency of Mutations in a Large Series of Clinically Ascertained Ovarian Cancer Cases tested on Multi-Gene Panels Compared to Reference Controls
  Gynecologic Oncology
• Dysproteinemias and Glomerular Disease
  Clinical Journal of the American Society of Nephrology
• Outcome of Surgical Repair of Pulmonary Artery Aneurysms: A Single-Center Experience With 38 Patients
  Journal of Clinical Microbiology
• Breast Cancer-Related Paraneoplastic Neurologic Disease
  Breast Cancer Research and Treatment
• Whole Blood mRNA Expression-Based Prognosis of Metastatic Renal Cell Carcinoma
  International Journal of Molecular Sciences
• ACR Appropriateness Criteria^® Radiologic Management of Central Venous Access
  Journal of the American College of Radiology
• Intracranial Melanotic Schwannomas: A Rare Variant with Unusual Adherent Features
  Journal of Neuro-Oncology
• Estimating Prognosis at the Time of Repeat Whole Brain Radiation Therapy for Multiple Brain Metastases: The Reirradiation Score
  Advances in Radiation Oncology
• Early Response Index: A Statistic to Discover Potential Early Stage Disease Biomarkers
  BMC Bioinformatics
• Cytomegalovirus (CMV) DNA Quantification in Bronchoalveolar Lavage Fluid of Immunocompromised Patients with CMV Pneumonia
  Clinical Transplantation
• Magnetic Resonance Imaging Appearance of Schwannomas from Head to Toe: A Pictorial Review
  Journal of Clinical Imaging Science

Kelley Luedke

Kelley Luedke is a Marketing Channel Manager at Mayo Clinic Laboratories. She is the principle editor and writer of Insights and leads social media and direct marketing strategy. Kelley has worked at Mayo Clinic since 2013. Outside of work, you can find Kelley running, traveling, playing with her kitty, and exploring new foods.