Mayo Clinic Laboratory and Pathology Research Roundup: Nov. 20
The Research Roundup provides an overview of the past week’s research from Mayo Medical Laboratories consultants, including featured abstracts and a complete list of published studies and reviews.
Featured Abstract
Prehospital Transfusion for Gastrointestinal Bleeding
Gastrointestinal (GI) bleeding is a common medical emergency with significant morbidity and mortality. Many patients are coagulopathic, which may perpetuate bleeding. Remote damage control resuscitation, including early correction of coagulopathy and anemia, may benefit exsanguinating patients with GI bleeding. Mayo Clinic researchers conducted a retrospective review of patients with acute GI bleeding who received packed red blood cells (pRBC) and/or plasma during transportation to our institution between 2010 and 2014. A comparison group of patients who were not transfused en route was selected, and demographics, outcomes, and response to resuscitation were compared. Prehospital damage control resuscitation with pRBC and/or plasma resulted in the improvement of hemodynamic instability, coagulopathy, and anemia in patients with acute GI bleeding. Almost all patients required additional inpatient interventions and/or transfusions, suggesting that pre-hospital transfusion is being utilized for appropriately selected patients. The study was published in Air Medical Journal.
Published to PubMed This Week
- Multicenter Validation of Enhancer of Zeste Homolog 2 Expression as an Independent Prognostic Marker in Localized Clear Cell Renal Cell Carcinoma
Journal of Clinical Oncology - Perioperative Morbidity of Lymph Node Dissection for Renal Cell Carcinoma: A Propensity Score-based Analysis
European Urology - Retention of Interstitial Genes Between TMPRSS2 and ERG is Associated with Low-Risk Prostate Cancer
Cancer Research - Purkinje Cell Cytoplasmic Antibody Type I (anti-Yo): Predictive of Gastrointestinal Adenocarcinomas in Men
Journal of Neurology, Neurosurgery, and Psychiatry - Myocardial Cobalt Levels Are Elevated in the Setting of Total Hip Arthroplasty
Journal of Bone and Joint Surgery - Activity of Ceftolozane/Tazobactam Against Carbapenem-Resistant, Carbapenemase Non-Producing Pseudomonas aeruginosa and Associated Resistance Mechanisms
Antimicrobial Agents and Chemotherapy - Syndromic Panel-Based Testing in Clinical Microbiology
Clinical Microbiology Reviews - Copper Deposition in Focal Nodular Hyperplasia and Inflammatory Hepatocellular Adenoma
Journal of Clinical Pathology - Undifferentiated Pancreatic Carcinomas Display Enrichment for Frequency and Extent of PD-L1 Expression by Tumor Cells
American Journal of Clinical Pathology - Flow Cytometric Assessment of Chronic Myeloid Neoplasms
Clinics in Laboratory Medicine - In situ Neoplasia in Lymph Node Pathology
Seminars Diagnostic Pathology - PDGFB Rearrangements in Dermatofibrosarcoma Protuberans of the Vulva: A Study of 11 Cases Including Myxoid and Fibrosarcomatous Variants
International Journal of Gynecological Pathology