Mayo Clinic Laboratory and Pathology Research Roundup: Dec. 4

By Kelley Luedke • December 4, 2017

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The Research Roundup provides an overview of the past week’s research from Mayo Medical Laboratories consultants, including featured abstracts and complete list of published studies and reviews.

Featured Abstract

Extensive Virologic and Immunologic Characterization in an HIV-Infected Individual following Allogeneic Stem Cell Transplant and Analytic Cessation of Antiretroviral Therapy

Notwithstanding 1 documented case of HIV-1 cure following allogeneic stem cell transplantation (allo-SCT), several subsequent cases of allo-SCT in HIV-1 positive individuals have failed to cure HIV-1 infection. Mayo Clinic researchers aimed to describe changes in the HIV reservoir in a single chronically HIV-infected patient on suppressive antiretroviral therapy who underwent allo-SCT for treatment of acute lymphoblastic leukemia. Researchers prospectively collected peripheral blood mononuclear cells (PBMCs) by leukapheresis from a 55-year-old man with chronic HIV infection before and after allo-SCT to measure the size of the HIV-1 reservoir and characterize viral phylogeny and phenotypic changes in immune cells. allo-SCT led to a significant reduction in the size of the HIV-1 reservoir and a >9-month-long ART-free remission from HIV-1 replication. Phylogenetic analyses suggest that the origin of rebound virus was distinct from the viruses identified pre-transplant in the PBMCs. The study was published in PLoS Medicine.

Published to PubMed This Week

• PTEN Loss Promotes Intratumoral Androgen Synthesis and Tumor Microenvironment Remodeling via Aberrant Activation of RUNX2 in Castration-Resistant Prostate Cancer
  Clinical Cancer Research
• Outcomes Among U.S. Patients with Diffuse Large B Cell Lymphoma are Independent of Tumor Epstein Barr Virus Positivity or Immunosuppression
  Haematologica
• Driver Mutations and Prognosis in Primary Myelofibrosis: Mayo-Careggi MPN Alliance Study of 1,095 Patients
  American Journal of Hematology
• Liver Dysfunction in Chronic Lymphocytic Leukemia: Prevalence, Outcomes, and Pathological Findings
  American Journal of Hematology
• Nucleophosmin 1 (NPM1) Mutations in Chronic Myelomonocytic Leukemia and Their Prognostic Relevance
  American Journal of Hematology
• POEMS Syndrome: An Elusive Diagnosis
  American Journal of Hematology
• Targeted Next-Generation Sequencing in Myelodysplastic Syndromes and Prognostic Interaction Between Mutations and IPSS-R
  American Journal of Hematology
• Comparison of a Sentinel Lymph Node Mapping Algorithm and Comprehensive Lymphadenectomy in the Detection of Stage IIIC Endometrial Carcinoma at Higher Risk for Nodal Disease
  Gynecologic Oncology
• Myocardial Cobalt Levels Are Elevated in the Setting of Total Hip Arthroplasty
  Journal of Bone and Joint Surgery
• Screening for ASXL1 and SRSF2 Mutations is Imperative for Treatment Decision-Making in Otherwise Low or Intermediate-1 Risk Patients with Myelofibrosis
  British Journal of Haematology
• Macrophagic "Crown-Like Structures" are Associated with an Increased Risk of Breast Cancer in Benign Breast Disease
  Cancer Prevention Research
• Is Axillary Surgery Beneficial for Patients with Adenoid Cystic Carcinoma of the Breast?
  Journal of Surgical Oncology
• Allelic Spectrum of Formiminotransferase-Cyclodeaminase Gene Variants in Individuals with Formiminoglutamic Aciduria
  Molecular Genetics & Genomic Medicine
• A Comprehensive Analysis of Breast Cancer Microbiota and Host Gene Expression
  PLoS One
• Cardiovascular Phenotype in Smad3 Deficient Mice with Renovascular Hypertension
  PLoS One
• Identification of a Pyruvate-to-Lactate Signature in Pancreatic Intraductal Papillary Mucinous Neoplasms
  Pancreatology
• Are High-Sensitivity Cardiac Troponin I Values Stable Between Preoperative Visit and Day of Non-Cardiac Surgery?
  Clinical Biochemistry
• Virtual Journal Club: An Example of the Growing Importance of Social Media in Pathology
  Cardiovascular Pathology
• A Case of Cutaneous Large B-Cell Lymphoma During Treatment of Multiple Sclerosis with Fingolimod
  Multiple Sclerosis and Related Disorders
• Advanced Cardiac Imaging Techniques Assist in Characterizing a Cardiac Mass and Directing Management
  Echocardiography
• Successful Nonmyeloablative Allogeneic Stem Cell Transplant in a Child With Emberger Syndrome and GATA2 Mutation
  Journal of Pediatric Hematology/Oncology

Kelley Luedke

Kelley Luedke is a Marketing Channel Manager at Mayo Clinic Laboratories. She is the principle editor and writer of Insights and leads social media and direct marketing strategy. Kelley has worked at Mayo Clinic since 2013. Outside of work, you can find Kelley running, traveling, playing with her kitty, and exploring new foods.