Mayo Clinic Laboratory and Pathology Research Roundup: Dec. 25

By Kelley Luedke • December 25, 2017

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The Research Roundup provides an overview of the past week’s research from Mayo Medical Laboratories consultants, including featured abstracts and complete list of published studies and reviews.

Featured Abstract

Global Pulmonary Vascular Remodeling in Pulmonary Hypertension Associated with Heart Failure and Preserved or Reduced Ejection Fraction

Mayo Clinic researchers hypothesized that pulmonary venous hypertension in heart failure leads to predominate remodeling of pulmonary veins and that the severity of venous remodeling is associated with the severity of pulmonary hypertension in heart failure. Based on study results, researchers found that in heart failure, pulmonary hypertension is associated with global pulmonary vascular remodeling but the severity of pulmonary hypertension correlates most strongly with venous and small IV intimal thickening, similar to the pattern observed in primary pulmonary veno-occlusive disease. These findings expand our understanding of the pathobiology of pulmonary hypertension in heart failure. The study was published in Circulation.

Published to PubMed This Week

• • • Undetectable Negative Tissue Transglutaminase IgA Antibodies Predict Mucosal Healing in Treated Coeliac Disease Patients
      Alimentary Pharmacology & Therapeutics
    • Association Between Mammographic Breast Density and Histologic Features of Benign Breast Disease
      Breast Cancer Research
    • Mutations and Karyotype in Myelodysplastic Syndromes: TP53 Clusters with Monosomal Karyotype, RUNX1 with Trisomy 21, and SF3B1 with inv(3)(q21q26.2) and del(11q)
      Blood Cancer Journal
    • Marked Elevation of Serum Lactate Dehydrogenase in Primary Myelofibrosis: Clinical and Prognostic Correlates
      Blood Cancer Journal
    • Survival in Response to Multimodal Therapy in Anaplastic Thyroid Cancer
      Journal of Clinical Endocrinology and Metabolism
    • Therapy Related-Chronic Myelomonocytic Leukemia (CMML): Molecular, Cytogenetic, and Clinical Distinctions from de novo CMML
      American Journal of Hematology
    • Technical Advances for the Clinical Genomic Evaluation of Sudden Cardiac Death: Verification of Next-Generation Sequencing Panels for Hereditary Cardiovascular Conditions Using Formalin-Fixed Paraffin-Embedded Tissues and Dried Blood Spots
      Circulation

Kelley Luedke

Kelley Luedke is a Marketing Channel Manager at Mayo Clinic Laboratories. She is the principle editor and writer of Insights and leads social media and direct marketing strategy. Kelley has worked at Mayo Clinic since 2013. Outside of work, you can find Kelley running, traveling, playing with her kitty, and exploring new foods.