Mayo Clinic Laboratory and Pathology Research Roundup: Feb. 19

By Kelley Luedke • February 19, 2018

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The Research Roundup provides an overview of the past week’s research from Mayo Medical Laboratories consultants, including featured abstracts and complete list of published studies and reviews.

Featured Abstract

Genomic Analysis Using Regularized Regression in High-Grade Serous Ovarian Cancer

High-grade serous ovarian cancer (HGSOC) is a complex disease in which initiation and progression have been associated with copy number alterations, epigenetic processes, and, to a lesser extent, germline variation. Mayo Clinic researchers hypothesized that, when summarized at the gene level, tumor methylation and germline genetic variation, alone or in combination, influence tumor gene expression in HGSOC. Researchers used Elastic Net (ENET) penalized regression method to evaluate these associations and adjust for somatic copy number in 3 independent data sets comprising tumors from more than 470 patients. Penalized regression models of germline variation, with or without methylation, did not reveal a role in HGSOC gene expression. However, researchers observed significant association between regional methylation and expression of 5 genes (WDPCP, KRT6C, BRCA2, EFCAB13, and ZNF283). CpGs retained in ENET model for BRCA2 and ZNF283 appeared enriched in several regulatory elements, suggesting that regularized regression may provide a novel utility for integrative genomic analysis. The study was published in Cancer Informatics.

Published to PubMed This Week

• • Primary Central Nervous System Vasculitis Associated with Lymphoma
    Neurology
  • Tau-Negative Amnestic Dementia Masquerading as Alzheimer Disease Dementia
    Neurology
  • Enterococcus faecalis Sex Pheromone cCF10 Enhances Conjugative Plasmid Transfer In Vivo
    MBio
  • Factors Associated With Positive Margins in Women Undergoing Breast Conservation Surgery
    Mayo Clinic Proceedings
  • Prognostic Interaction Between Bone Marrow Morphology and SF3B1 and ASXL1 Mutations in Myelodysplastic Syndromes with Ring Sideroblasts
    Blood Cancer Journal
  • Simulation-based Transfusion Education for Medical Students
    Transfusion Medicine Reviews
  • Ophthalmic Findings of Rosai-Dorfman Disease
    American Journal of Ophthalmology
  • Perioperative Inpatient Use of Selective Serotonin Reuptake Inhibitors Is Associated With a Reduced Risk of THA and TKA Revision
    Clinical Orthopaedics and Related Research
  • Evaluation of a Commercial Multiplex Molecular Panel For the Diagnosis of Infectious Meningitis and Encephalitis
    Journal of Clinical Microbiology
  • Clinical Review of the Pharmacogenomics of Direct Oral Anticoagulants
    Cardiovascular Drugs and Therapy
  • Phosphaturic Mesenchymal Tumors: What an Endocrinologist Should Know
    Journal of Endocrinological Investigation
  • Duration of Group A Streptococcus PCR Positivity Following Antibiotic Treatment of Pharyngitis
    Diagnostic Microbiology and Infectious Disease

Kelley Luedke

Kelley Luedke is a Marketing Channel Manager at Mayo Clinic Laboratories. She is the principle editor and writer of Insights and leads social media and direct marketing strategy. Kelley has worked at Mayo Clinic since 2013. Outside of work, you can find Kelley running, traveling, playing with her kitty, and exploring new foods.