Mayo Clinic Laboratory and Pathology Research Roundup: March 2

By Kelley Luedke • March 5, 2018

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The Research Roundup provides an overview of the past week’s research from Mayo Medical Laboratories consultants, including featured abstracts and complete list of published studies and reviews.

Featured Abstract

High Grade B-Cell Lymphoma with MYC and BCL2 and/or BCL6 Rearrangements with Diffuse Large B-Cell Lymphoma Morphology

High grade B-cell lymphoma with MYC and BCL2 and/or BCL6 rearrangements (HGBL-DH/TH) is a newly defined entity in the latest World Health Organization Classification. Accurate diagnosis would appear to mandate fluorescence in situ hybridization (FISH) for all tumors with diffuse large B-cell lymphoma (DLBCL) morphology. Mayo Clinic researchers present the results of FISH, cell-of-origin, and immunohistochemistry (IHC) testing from 1228 DLBCL biopsies from three clinical trials and a population-based registry. The results provide accurate estimation of the proportion of HGBL-DH/TH among tumors with DLBCL morphology and allow determination of the impact of various methods available to screen DLBCL tumors for FISH testing. The study was published in Blood.

Published to PubMed This Week

• • • • • Prognostic Significance of Circulating Plasma Cells by Multi-Parametric Flow Cytometry in Light Chain Amyloidosis
          Leukemia
        • Revised Cytogenetic Risk Stratification in Primary Myelofibrosis: Analysis Based on 1002 Informative Patients
          Leukemia
        • Cohort Profile: The Colon Cancer Family Registry Cohort (CCFRC)
          International Journal of Epidemiology
        • Bilateral Corneal Deposits 1 Week After Starting Oral Prednisone Therapy
          JAMA Ophthalmology
        • Differential Effect of Amyloid Beta Peptides on Mitochondrial Axonal Trafficking Depends on Their State of Aggregation and Binding to the Plasma Membrane
          Neurobiology of Disease
        • Fatty Acid Synthase is Required for Profibrotic TGF-β Signaling
          FASEB J
        • Comparison of the Effect of Daily Versus Bolus Dose Maternal Vitamin D Supplementation on the 24,25-dihydroxyvitamin D to 25-hydroxyvitamin D Ratio
          Bone
        • Colonoscopy Surveillance for High Risk Polyps Does Not Always Prevent Colorectal Cancer
          World Journal of Gastroenterology
        • Fatty Acid Synthase is Required for Profibrotic TGF-β Signaling
          FASEB J
        • The Use of Cytapheresis in the Treatment of Infectious Diseases
          Journal of Clinical Apheresis
        • Targeted Next-Generation Sequencing in Blast Phase Myeloproliferative Neoplasms
          Blood Advances

Kelley Luedke

Kelley Luedke is a Marketing Channel Manager at Mayo Clinic Laboratories. She is the principle editor and writer of Insights and leads social media and direct marketing strategy. Kelley has worked at Mayo Clinic since 2013. Outside of work, you can find Kelley running, traveling, playing with her kitty, and exploring new foods.