Mayo Clinic Laboratory and Pathology Research Roundup: March 26

By Kelley Luedke • March 26, 2018

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The Research Roundup provides an overview of the past week’s research from Mayo Medical Laboratories consultants, including featured abstracts and complete list of published studies and reviews.

Featured Abstract

Development of a Microscopic Colitis Disease Activity Index: A Prospective Cohort Study

Microscopic colitis (MC) is a common cause of chronic diarrhoea, often with additional symptoms. No validated instruments exist to assess disease activity in MC, making it difficult to compare efficacy of treatments between clinical trials. Mayo Clinic researchers aimed to identify clinical features that independently predicted disease severity and to create a microscopic colitis disease activity index (MCDAI). Patients with MC were prospectively administered a survey assessing their GI symptoms and the IBD questionnaire (IBDQ). A single investigator also scored a physician global assessment (PGA) of disease severity on a 10-point scale. Multiple linear regression identified which symptoms best predicted the PGA. These symptoms were then combined in a weighted formula to create the MCDAI. The relationship between MCDAI and the IBDQ was investigated. The MCDAI strongly predicted the PGA and correlated with a validated measure of quality of life. Several symptoms in addition to diarrhoea are associated with disease severity in MC. The study was published in Gut.

Published to PubMed This Week

• • • • • Folate Receptor Alpha Peptide Vaccine Generates Immunity in Breast and Ovarian Cancer Patients
          Clinical Cancer Research
        • Diagnostic Stewardship: Opportunity for a Laboratory-Infectious Diseases Partnership
          Clinical Infectious Diseases
        • Mediastinal Synovial Sarcoma: Clinicopathologic Analysis of 21 Cases With Molecular Confirmation
          American Journal of Surgical Pathology
        • Thyroglobulin Measurement in the Management of Patients with Differentiated Thyroid Cancer
          Critical Reviews in Clinical Laboratory Sciences
        • Uterine Serous Carcinoma: Reassessing Effectiveness of Platinum-Based Adjuvant Therapy
          Gynecologic Oncology
        • Blood Gas Sample Spiking with Total Parenteral Nutrition, Lipid Emulsion, and Concentrated Dextrose Solutions as a Model for Predicting Sample Contamination Based on Glucose Result
          Clinical Biochemistry

Kelley Luedke

Kelley Luedke is a Marketing Channel Manager at Mayo Clinic Laboratories. She is the principle editor and writer of Insights and leads social media and direct marketing strategy. Kelley has worked at Mayo Clinic since 2013. Outside of work, you can find Kelley running, traveling, playing with her kitty, and exploring new foods.