Mayo Clinic Laboratory and Pathology Research Roundup: May 28

By Kelley Luedke • May 28, 2018

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The Research Roundup provides an overview of the past week’s research from Mayo Medical Laboratories consultants, including featured abstracts and complete list of published studies and reviews.

Featured Abstract

Clinical and Pathology Findings Associate Consistently with Larger Glomerular Volume

Glomerular volume increases when demand exceeds nephron supply, which may lead to glomerulosclerosis. It is unclear if determinants of glomerular volume are consistent between populations that differ by severity of comorbidities. Mayo Clinic researchers studied kidney biopsy specimens from living kidney donors and patients who underwent radical nephrectomy for a renal tumor. They scanned specimen sections into high-resolution digital images, manually traced glomerular profiles, and calculated mean glomerular volumes using the Weibel-Gomez stereologic formula. Researchers then assessed the relationship of glomerular volume with age, clinical characteristics, and nephrosclerosis on biopsy specimen. The researchers found that compared with kidney donors, patients with tumors were older and more frequently men, obese, diabetic, or hypertensive, had more glomerulosclerosis and interstitial fibrosis on biopsy specimen, and had 12% larger nonsclerosed glomeruli. In both populations, male sex, taller height, obesity, hypertension, and proteinuria associated with larger nonsclerosed glomeruli to a similar extent. In patients with tumors, diabetes, glomerulosclerosis, and interstitial fibrosis also associated with larger nonsclerosed glomeruli. Independent clinical predictors of larger nonsclerotic glomeruli were family history of ESRD, male sex, taller height, obesity, diabetes, and proteinuria. After adjustment for these characteristics, nonsclerotic glomerular volume did not differ between populations and was stable up to age 75 years, after which it decreased with age. Many of these findings were also evident with globally sclerotic glomerular volume. Researchers concluded that characteristics associated with glomerular volume are consistent between patient populations with low and high levels of comorbidity. The study was published in the Journal of American Society of Nephrology.

Published to PubMed This Week

• • • • • Incidence of Major Hemorrhage After Aggressive Image-Guided Liver Mass Biopsy in the Era of Individualized Medicine
          Abdominal Radiology
        • BRCA1/2 Mutations and Bevacizumab in the Neoadjuvant Treatment of Breast Cancer: Response and Prognosis Results in Patients With Triple-Negative Breast Cancer From the GeparQuinto Study
          Journal of Clinical Oncology
        • Constitutive Interferon Pathway Activation in Tumors as an Efficacy Determinant Following Oncolytic Virotherapy
          Journal of the National Cancer Institute
        • Genotype-Phenotype Correlation of Hereditary Erythrocytosis Mutations, A Single Center Experience
          American Journal of Hematology
        • Use of Genetic Testing for Primary Immunodeficiency Patients
          Journal of Clinical Immunology
        • Analytical Performance of an Immunoassay to Measure Proenkephalin
          Clinical Biochemistry

Kelley Luedke

Kelley Luedke is a Marketing Channel Manager at Mayo Clinic Laboratories. She is the principle editor and writer of Insights and leads social media and direct marketing strategy. Kelley has worked at Mayo Clinic since 2013. Outside of work, you can find Kelley running, traveling, playing with her kitty, and exploring new foods.