Mayo Clinic Laboratory and Pathology Research Roundup: June 4

By Kelley Luedke • June 4, 2018

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The Research Roundup provides an overview of the past week’s research from Mayo Medical Laboratories consultants, including featured abstracts and complete list of published studies and reviews.

Featured Abstract

Isolated Hepatic Non-Obstructive Sinusoidal Dilatation, 20-Year Single Center Experience

Mayo Clinic researchers conducted a study to characterize isolated non-obstructive sinusoidal dilatation (SD) by identifying associated conditions, laboratory findings, and histological patterns. They identified 88 patients with non-obstructive SD. Inflammatory conditions were the most common cause. The most common pattern of liver abnormalities was cholestatic. The majority had localized SD to Zone III. Medication-related SD had higher proportion of portal hypertension, ascites, and median AST and ALT levels. Nineteen patients in the study died within one-year after diagnosis of SD, majority from complications related to underlying diseases. Based on the findings, a significant proportion of SD and hepatocellular plate atrophy exist without impaired hepatic venous outflow. Isolated SD on liver biopsy, in the absence of congestive hepatopathy, requires further evaluation and portal hypertension should be ruled out. The study was published in the World Journal of Hepatology.

Published to PubMed This Week

• • • • • TMPRSS2-ERG Controls Luminal Epithelial Lineage and Antiandrogen Sensitivity in PTEN and TP53-Mutated Prostate Cancer
          Clinical Cancer Research
        • Human Pegivirus Infection and Lymphoma Risk and Prognosis: A North American Study
          British Journal of Haematology
        • Methodology, Criteria and Characterization of Patient-Matched Thyroid Cell Lines and Patient-Derived Tumor Xenografts
          Journal of Clinical Endocrinology and Metabolism
        • Pharmacokinetics of Rituximab and Clinical Outcomes in Patients with Anti-Neutrophil Cytoplasmic Antibody Associated Vasculitis
          Rheumatology
        • A Comprehensive Approach to Sequence-Oriented IsomiR Annotation (CASMIR): Demonstration with IsomiR Profiling in Colorectal Neoplasia
          BMC Genomics

Kelley Luedke

Kelley Luedke is a Marketing Channel Manager at Mayo Clinic Laboratories. She is the principle editor and writer of Insights and leads social media and direct marketing strategy. Kelley has worked at Mayo Clinic since 2013. Outside of work, you can find Kelley running, traveling, playing with her kitty, and exploring new foods.