Mayo Clinic Laboratory and Pathology Research Roundup: July 2

By Kelley Luedke • July 2, 2018

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The Research Roundup provides an overview of the past week’s research from Mayo Medical Laboratories consultants, including featured abstracts and complete list of published studies and reviews.

Featured Abstract

Comparison of Risk Stratification Models to Predict Recurrence and Survival in Pleuropulmonary Solitary Fibrous Tumor

Solitary fibrous tumors (SFT) are rare mesenchymal neoplasms. Most follow a benign course, but a subset will recur or metastasize. Various risk stratification schemes have been proposed for SFT, but none have been universally endorsed and few have focused on pleuropulmonary SFT. Histologic sections were examined from surgically resected pleuropulmonary SFT, with confirmatory immunohistochemistry. Patients were risk stratified using 4 prediction models as proposed by de Perrot, Demicco (original and modified), and Tapias. Kaplan-Meier analysis estimated overall survival and progression-free survival (PFS). Risk scoring systems proposed by Tapias and Demicco were both predictive of OS and PFS. The Demicco system has the advantages of simplicity and applicability to SFTs from other sites, as well as providing best discrimination for PFS, and thus may be the best system to apply in general practice. The study was published in the Journal of Thoracic Oncology.

Published to PubMed This Week

• • • • • CNS Relapse in Patients with DLBCL Treated with Lenalidomide Plus R-CHOP (R2CHOP): Analysis from Two Phase 2 Studies
          Blood Cancer Journal
        • Evaluation of 2 Breast Cancer Risk Models in a Benign Breast Disease Cohort
          Cancer
        • Banff Survey on Antibody Mediated Rejection Clinical Practices in Kidney Transplantation: Diagnostic Misinterpretation has Potential Therapeutic Implications
          American Journal of Transplantation
        • Development and Verification of an RNA Sequencing (RNA-Seq) Assay for the Detection of Gene Fusions in Tumors
          Journal of Molecular Diagnostics
        • Treatment Outcomes for Pleomorphic Lobular Carcinoma In Situ of the Breast
          Annals of Surgical Oncology
        • Incidence and Epidemiology of Perioperative Transfusion-Related Pulmonary Complications in Pediatric Noncardiac Surgical Patients: A Single-Center, 5-Year Experience
          Anesthesia & Analgesia
        • Mixed-Phenotype Large Granular Lymphocytic Leukemia (LGLL): A Rare Subtype in the LGLL Spectrum
          Human Pathology
        • Surveillance After Prostate Focal Therapy
          World Journal of Urology
        • The Impact of Eculizumab on Routine Complement Assays
          Journal of Immunological Methods
        • Improving Single-Nucleotide Polymorphism-Based Fetal Fraction Estimation of Maternal Plasma Circulating Cell-Free DNA Using Bayesian Hierarchical Models
          Journal of Computational Biology

Kelley Luedke

Kelley Luedke is a Marketing Channel Manager at Mayo Clinic Laboratories. She is the principle editor and writer of Insights and leads social media and direct marketing strategy. Kelley has worked at Mayo Clinic since 2013. Outside of work, you can find Kelley running, traveling, playing with her kitty, and exploring new foods.