Mayo Clinic Laboratory and Pathology Research Roundup: July 23

By Kelley Luedke • July 23, 2018

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The Research Roundup provides an overview of the past week’s research from Mayo Medical Laboratories consultants, including featured abstracts and complete list of published studies and reviews.

Featured Abstract

Gastrointestinal and Extra-intestinal Manifestations of Immunoglobulin G4-Related Disease

Immunoglobulin G4-related disease (IgG4-RD) is a chronic relapsing multi-organ fibro-inflammatory syndrome of presumed autoimmune etiology. It is characterized by increased serum levels of IgG subclass 4 (IgG4) and tissue infiltration by IgG4+ cells. Increased titers of autoantibodies against a spectrum of self-antigens and response to steroids have led to its characterization as an autoimmune disease. However, the pathognomonic antigens probably differ among manifestations, and different antigens or autoantibodies produce similar immune reactions in different organs. Little is known about the pathogenic effects, if any, of serum IgG4 or IgG4+ plasma cells in tissues. Despite several animal models of the disease, none truly recapitulates human IgG4-RD. Histologic analyses of tissues from patients with IgG4-RD reveal a dense lympho-plasmacytic infiltrate rich in IgG4+ plasma cells, storiform fibrosis, and obliterative phlebitis, although these features vary among organs. Typical presentation and imaging findings include mass-forming synchronous or metachronous lesions in almost any organ, but most commonly in the pancreas, bile duct, retroperitoneum, kidneys, lungs, salivary and lacrimal glands, orbit, and lymph nodes. In all organs, inflammation can be reduced by corticosteroids and drugs that deplete B cells such as rituximab. Patients with IgG4-RD have relapses that respond to primary therapy. Intense fibrosis accompanies the inflammatory response, leading to permanent organ damage and insufficiency. Death from IgG4-RD is rare. IgG4-RD is a multi-organ disease with predominant pancreatico-biliary involvement. Despite its relapsing-remitting course, patients have an excellent prognosis. The study was published in the Gastroenterology.

Published to PubMed This Week

• • • • • The Probability of Aggressive Versus Indolent Histology Based on Renal Tumor Size: Implications for Surveillance and Treatment
          European Urology
        • The Utility of MR Elastography to Differentiate Nodular Regenerative Hyperplasia from Cirrhosis
          Hepatology
        • Association of MOG-IgG Serostatus With Relapse After Acute Disseminated Encephalomyelitis and Proposed Diagnostic Criteria for MOG-IgG-Associated Disorders
          JAMA Neurology
        • Blood Gas Sample Spiking with Total Parenteral Nutrition, Lipid Emulsion, and Concentrated Dextrose Solutions as a Model for Predicting Sample Contamination Based on Glucose Result
          Clinical Biochemistry
        • Evaluation of Oritavancin in Combination with Rifampin, Gentamicin or Linezolid Against Prosthetic Joint Infection-Associated Methicillin-Resistant Staphylococcus aureus Biofilms by Time-Kill Assays
          Antimicrobial Agents and Chemotherapy
        • Diagnostic Approach for Classic Compared With Localized Whipple Disease
          Open Forum Infectious Diseases
        • The Murine Dialysis Fistula Model Exhibits a Senescence Phenotype: Pathobiologic Mechanisms and Therapeutic Potential
          American Journal of Physiology-Renal Physiology
        • Computer-Aided Diagnosis of Contrast-Enhanced Spectral Mammography: A Feasibility Study
          European Journal of Radiology
        • Sub-Classifying Patients with Mild Traumatic Brain Injury: A Clustering Approach Based on Baseline Clinical Characteristics and 90-Day and 180-Day Outcomes
          PLoS One
        • Identifying a Newly Discovered HLA-C Allele: HLA-C*02:138
          HLA
        • Prognostic Impact of ASXL1 Mutations in Patients with Myelodysplastic Syndromes and Multilineage Dysplasia With or Without Ring Sideroblasts
          Leukemia Research
        • Adenomatous Neuroendocrine Tumors of the Middle Ear: A Multi-institutional Investigation of 32 Cases and Development of a Staging System
          Otology & Neurotology
        • Serum 25-Hydroxyvitamin D3 Levels and Flares of Systemic Lupus Erythematosus: A Longitudinal Cohort Analysis
          Clinical Rheumatology
        • Elevated ST2 Levels are Associated with Antibody Mediated Rejection in Heart Transplant Recipients
          Clinical Transplantation
        • Autoimmune Septin-5 Cerebellar Ataxia
          Neurology Neuroimmunology & Neuroinflammation

Kelley Luedke

Kelley Luedke is a Marketing Channel Manager at Mayo Clinic Laboratories. She is the principle editor and writer of Insights and leads social media and direct marketing strategy. Kelley has worked at Mayo Clinic since 2013. Outside of work, you can find Kelley running, traveling, playing with her kitty, and exploring new foods.