Mayo Clinic Laboratory and Pathology Research Roundup: Sept. 3

By Kelley Luedke • September 3, 2018

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The Research Roundup provides an overview of the past week’s research from Mayo Medical Laboratories consultants, including featured abstracts and complete list of published studies and reviews.

Featured Abstract

Biphenotypic Acute Leukemia versus Myeloid Antigen-Positive ALL: Clinical Relevance of WHO Criteria for Mixed Phenotype Acute Leukemia

Updated WHO criteria define mixed phenotype acute leukemia (MPAL) with more stringent diagnostic criteria than the formerly described entity biphenotypic acute leukemia (BAL). The changes in diagnostic criteria influence management by assigning weight to aberrantly expressed markers and minimizing expression of myeloid markers other than myeloperoxidase (MPO), potentially foregoing consolidative allogeneic transplant for an otherwise "favorable" lymphoid phenotypic leukemia. Mayo Clinic researchers present a case of MPO-negative, myeloid antigen-positive acute lymphoblastic leukemia who progressed with refractory phenotypic acute myeloid leukemia while receiving lymphoid-directed therapy and discuss concerns raised by the adoption of the new, more stringent diagnostic criteria for BAL. The study was published in Case Reports in Hematology.

Published to PubMed This Week

• • • • • Clinicopathologic Features and Outcomes of Gastrointestinal Stromal Tumors Arising from the Esophagus and Gastroesophageal Junction
          Journal of Gastrointestinal Oncology
        • Cancer Risks for PMS2-Associated Lynch Syndrome
          Journal of Clinical Oncology
        • Age-Specific Genome-Wide Association Study in Glioblastoma Identifies Increased Proportion of 'Lower Grade Glioma'-Like Features Associated with Younger Age
          International Journal of Cancer
        • Cytogenetic Abnormalities in Systemic Mastocytosis: WHO Subcategory-Specific Incidence and Prognostic Impact Among 348 Informative Cases
          American Journal of Hematology
        • Mutations and Karyotype Predict Treatment Response in Myelodysplastic Syndromes
          American Journal of Hematology
        • Myeloproliferative Neoplasms in the Young: Mayo Clinic Experience with 361 Patients Age 40 Years or Younger
          American Journal of Hematology
        • Practice-Relevant Demarcation of Systemic Mastocytosis Associated with Another Hematologic Neoplasm (SM-AHN)
          American Journal of Hematology
        • A Cross-Study Analysis for Reproducible Sub-classification of Traumatic Brain Injury
          Frontiers in Neurology
        • An Approach to Analytical Validation and Testing of Body Fluid Assays for the Automated Clinical Laboratory
          Clinical Biochemistry
          
        • Analytical Performance of an Immunoassay to Measure Proenkephalin
          Clinical Biochemistry
          
        • Comparing the Performance of CA 15-3 CSF to Cytology in a Cohort of Patients with Breast Cancer Leptomeningeal Metastasis
          Clinical Biochemistry
          
        • False-Positive Amphetamine Results on Several Drug Screening Platforms Due to Mexiletine
          Clinical Biochemistry
          
        • Multiple Isodicentric Y Chromosomes in Myeloid Malignancies: A Unique Cytogenetic Entity and Potential Therapeutic Target
          Leukemia & Lymphoma
        • Randomized Controlled Trial of Silver-Alloy-Impregnated Suprapubic Catheters Versus Standard Suprapubic Catheters in Assessing Urinary Tract Infection Rates in Urogynecology Patients
          International Urogynecology Journal
          
        • The Association of de novo Anti-HLA-DPB1 Donor-Specific Antibody Formation and Primary Graft Failure After Allogeneic Hematopoietic Cell Transplantation
          Human Immunology

Kelley Luedke

Kelley Luedke is a Marketing Channel Manager at Mayo Clinic Laboratories. She is the principle editor and writer of Insights and leads social media and direct marketing strategy. Kelley has worked at Mayo Clinic since 2013. Outside of work, you can find Kelley running, traveling, playing with her kitty, and exploring new foods.