Mayo Clinic Laboratory and Pathology Research Roundup: Sept. 10
The Research Roundup provides an overview of the past week’s research from Mayo Medical Laboratories consultants, including featured abstracts and complete list of published studies and reviews.
Featured Abstract
Hepatocellular Carcinoma Detection by Plasma Methylated DNA: Discovery, Phase I Pilot, and Phase II Clinical Validation
Early detection improves hepatocellular carcinoma (HCC) outcomes, but better noninvasive surveillance tools are needed. Mayo Clinic researchers aimed to identify and validate methylated DNA markers (MDMs) for HCC detection. Reduced representation bisulfite sequencing was performed on DNA extracted from 18 HCC and 35 control tissues. A phase I plasma pilot incorporated quantitative allele-specific real time target and signal amplification assays on independent plasma-extracted DNA from 21 HCC cases and 30 cirrhotic controls. A phase II plasma study was then performed in 95 HCC cases, 51 cirrhosis controls, and 98 healthy controls using target enrichment long-probe quantitative amplified signal (TELQAS) assays. Based on the results, novel MDMs identified in this study proved to accurately detect HCC via plasma testing. Further optimization and clinical testing of this promising approach are indicated. The study was published in Case Reports in Hepatology.
Published to PubMed This Week
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- Tyrosine Phosphorylation of Mitochondrial Creatine Kinase 1 Enhances a Druggable Tumor Energy Shuttle Pathway
Cell Metabolism - Use of High-Sensitivity Cardiac Troponin in Patients With Chronic Comorbidities: Moving From Theory to Practice
Journal of the American College of Cardiology - A Guide to Utilization of the Microbiology Laboratory for Diagnosis of Infectious Diseases: 2018 Update by the Infectious Diseases Society of America and the American Society for Microbiology
Clinical Infectious Diseases - Ganglionic Antibody Level as a Predictor of Severity of Autonomic Failure
Mayo Clinic Proceedings - Recurrent Desmoid-Type Fibromatosis Associated with Underlying Neuromuscular Choristoma
Journal of Neurosurgery - A Pediatric Intra-Axial Malignant SMARCB1-Deficient Desmoplastic Tumor Arising in Meningioangiomatosis
Journal of Neuropathology & Experimental Neurology - DNA Methylation at the Vicinity of the Proximal Polyadenylation Site in FANCD2 Gene Involves Human Malignancy
Cell Cycle - Heterogeneity of Programmed Cell Death-Ligand 1 Expression in Thymic Epithelial Tumors Between Initial Specimen and Synchronous or Metachronous Metastases or Recurrences
Histopathology - A Method to Reduce Variability in Scoring Anti-Body Mediated Rejection in Renal Allografts: Implications for Clinical Trials
Transplant International
- Corded and Hyalinized Mesonephric-Like Adenocarcinoma of the Uterine Corpus: Report of a Case Mimicking Endometrioid Carcinoma
Human Pathology
- Reference Intervals: Comparison of Calculation Methods and Evaluation of Procedures for Merging Reference Measurements From Two US Medical Centers
American Journal of Clinical Pathology
- A Cavernous Sinus Lesion Clinically Responsive to Steroids
Journal of Clinical Neuroscience
- Tyrosine Phosphorylation of Mitochondrial Creatine Kinase 1 Enhances a Druggable Tumor Energy Shuttle Pathway
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