Mayo Clinic Laboratory and Pathology Research Roundup: Oct. 15

By Kelley Luedke • October 15, 2018

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The Research Roundup provides an overview of the past week’s research from Mayo Medical Laboratories consultants, including featured abstracts and complete list of published studies and reviews.

Featured Abstract

Mayo Clinic researchers conducted a study to describe paraneoplastic neuronal intermediate filament (NIF) autoimmunity. Archived patient and control serum and CSF specimens were evaluated by tissue-based indirect immunofluorescence assay (IFA). Autoantigens were identified by Western blot and mass spectrometry. NIF specificity was confirmed by dual tissue section staining and 5 recombinant NIF-specific HEK293 cell-based assays (CBAs, for α-internexin, neurofilament light [NfL], neurofilament medium, or neurofilament heavy chain, and peripherin). NIF-immunoglobulin Gs (IgGs) were correlated with neurologic syndromes and cancers. NIF-IgG detection by IFA, with confirmatory CBA testing that yields a profile including NfL-IgG, defines a paraneoplastic CNS disorder (usually ataxia or encephalopathy) accompanying neuroendocrine lineage neoplasia. The study was published in Neurology.

Published to PubMed This Week

• • • • • SD-CNN: A Shallow-Deep CNN for Improved Breast Cancer Diagnosis
          Computerized Medical Imaging and Graphics
        • Solitary Lung Nodule.
          Mayo Clinic Proceedings
        • Histiocyte-rich Rhabdomyoblastic Tumor: Rhabdomyosarcoma, Rhabdomyoma, or Rhabdomyoblastic Tumor of Uncertain Malignant Potential? A Histologically Distinctive Rhabdomyoblastic Tumor in Search of a Place in the Classification of Skeletal Muscle Neoplasms
          Modern Pathology
        • Cationic Carrier Peptide Enhances Cerebrovascular Targeting of Nanoparticles in Alzheimer's Disease Brain
          Nanomedicine
        • Diagnostic Utility of Complement Serology for Atypical Hemolytic Uremic Syndrome
          Mayo Clinic Proceedings
        • Medical Parasitology Taxonomy Update, 2016-2017
          Journal of Clinical Microbiology
        • Cardiac Troponin and Natriuretic Peptide Analytical Interferences from Hemolysis and Biotin: Educational Aids from the IFCC Committee on Cardiac Biomarkers (IFCC C-CB)
          Clinical Chemistry and Laboratory Medicine
        • Sellar Region Atypical Teratoid/Rhabdoid Tumors in Adults: Clinicopathological Characterization of Five Cases and Review of the Literature
          Journal of Neuropathology & Experimental Neurology
        • Open Staged Repair of Splenic and Extensive Superior Mesenteric Artery Aneurysms
          Journal of Vascular Surgery
        • Whole-Genome Sequencing for Methicillin-Resistant Staphylococcus Aureus (MRSA) Outbreak Investigation in a Neonatal Intensive Care Unit
          Infection Control & Hospital Epidemiology
        • Evaluation of the Siemens ADVIA Centaur High-Sensitivity Cardiac Troponin I Assay in Serum
          Clinica Chimica Acta
        • FGFR1 Rearranged Hematological Neoplasms - Molecularly Defined and Clinically Heterogeneous
          Leukemia & Lymphoma
        • Implementation of a Reformulated Roche® Bilirubin Gen.3 Reagent Did Not Affect the Relationship Between BiliChek Transcutaneous and Roche Total Serum Bilirubin
          Clinical Biochemistry
        • Role of Prolonged Blood Culture Incubation in Infective Endocarditis Diagnosis
          European Journal of Clinical Microbiology & Infectious Diseases
        • Activity of Fixed Direct Electrical Current in Experimental Staphylococcus Aureus Foreign-Body Osteomyelitis
          Diagnostic Microbiology and Infectious Disease

Kelley Luedke

Kelley Luedke is a Marketing Channel Manager at Mayo Clinic Laboratories. She is the principle editor and writer of Insights and leads social media and direct marketing strategy. Kelley has worked at Mayo Clinic since 2013. Outside of work, you can find Kelley running, traveling, playing with her kitty, and exploring new foods.