Mayo Clinic Laboratory and Pathology Research Roundup: Nov. 5

By Kelley Luedke • November 5, 2018

Share this:

The Research Roundup provides an overview of the past week’s research from Mayo Medical Laboratories consultants, including featured abstracts and complete list of published studies and reviews.

Featured Abstract

Gastrointestinal and Extra-Intestinal Manifestations of IgG4-Related Disease

IgG4-related disease (IgG4-RD) is a chronic relapsing multi-organ fibro-inflammatory syndrome of presumed autoimmune etiology. It is characterized by increased serum levels of IgG4 and tissue infiltration by IgG4+ cells. Increased titers of autoantibodies against a spectrum of self-antigens and response to steroids have led to its characterization as an autoimmune disease. However, the pathognomonic antigens probably differ among manifestations, and different antigens or autoantibodies produce similar immune reactions in different organs. Little is known about the pathogenic effects, if any, of serum IgG4 or IgG4+ plasma cells in tissues. Despite several animal models of the disease, none truly recapitulates human IgG4-RD. Histologic analyses of tissues from patients with IgG4-RD reveal a dense lymphoplasmacytic infiltrate rich in IgG4+ plasma cells, storiform fibrosis, and obliterative phlebitis, although these features vary among organs. Typical presentation and imaging findings include mass-forming synchronous or metachronous lesions in almost any organ, but most commonly in the pancreas, bile duct, retroperitoneum, kidneys, lungs, salivary and lacrimal glands, orbit, and lymph nodes. In all organs, inflammation can be reduced by corticosteroids and drugs that deplete B cells, such as rituximab. Patients with IgG4-RD have relapses that respond to primary therapy. Intense fibrosis accompanies the inflammatory response, leading to permanent organ damage and insufficiency. Death from IgG4-RD is rare. IgG4-RD is a multi-organ disease with predominant pancreatico-biliary involvement. Despite its relapsing-remitting course, patients have an excellent prognosis. The study was published in Gastroenterology.

Published to PubMed This Week

• • • • • Large Hepatic Mass in an Adolescent Male
          Gastroenterology
        • Clostridioides difficile Uses Amino Acids Associated with Gut Microbial Dysbiosis in a Subset of Patients with Diarrhea
          Science Translational Medicine
        • Activity of EGFR Antibody in Non-V600 BRAF Mutant Metastatic Colorectal Cancer
          Annals of Oncology
          
        • Multifocal Pulmonary Adenocarcinoma with Ground-Glass/Lepidic Features-Exciting Times as the Mystery Is Unfolding
          Journal of Thoracic Oncology
        • Distinct Microbes, Metabolites, and Ecologies Define the Microbiome in Deficient and Proficient Mismatch Repair Colorectal Cancers
          Genome Medicine
        • Multiplex Droplet Digital PCR Method Applicable to Newborn Screening, Carrier Status, and Assessment of Spinal Muscular Atrophy
          Clinical Chemistry
        • Transplantation of HCV-Infected Organs into Uninfected Recipients: Advance with Caution
          American Journal of Transplantation
        • A Randomized Trial of Three Novel Regimens for Recurrent Acute Myeloid Leukemia Demonstrates the Continuing Challenge of Treating this Difficult Disease
          American Journal of Hematology
        • Circulating Metabolic Biomarkers of Screen-Detected Prostate Cancer in the ProtecT Study
          Cancer Epidemiology, Biomarkers & Prevention
        • Physical Activity Monitors Can Be Successfully Implemented to Assess Perioperative Activity in Urologic Surgery
          mHealth
        • Copy Number Variant Analysis Using Genome-Wide Mate-Pair Sequencing
          Genes Chromosomes Cancer
        • Prevalence of Biotin Supplement Usage in Outpatients and Plasma Biotin Concentrations in Patients Presenting to the Emergency Department
          Clinical Biochemistry
          
        • Rose Geranium in Sesame Oil Nasal Spray: A Treatment for Nasal Vestibulitis?
          BMJ Supportive & Palliative Care
        • High-Sensitivity Troponin in Patients With Coronary Artery Endothelial Dysfunction
          Journal of Invasive Cardiology
        • What to Do When You Question Cardiac Troponin Values
          European Heart Journal: Acute Cardiovascular Care
        • How is Cardiac Troponin Released from Injured Myocardium?
          European Heart Journal: Acute Cardiovascular Care

Kelley Luedke

Kelley Luedke is a Marketing Channel Manager at Mayo Clinic Laboratories. She is the principle editor and writer of Insights and leads social media and direct marketing strategy. Kelley has worked at Mayo Clinic since 2013. Outside of work, you can find Kelley running, traveling, playing with her kitty, and exploring new foods.