Mayo Clinic Laboratory and Pathology Research Roundup: Jan. 14
The Research Roundup provides an overview of the past week’s research from Mayo Clinic Laboratories consultants, including featured abstracts and a complete list of published studies and reviews.
Featured Abstract
Identification of Prognostic Phenotypes of Esophageal Adenocarcinoma in 2 Independent Cohorts
Most patients with esophageal adenocarcinoma (EAC) present with de novo tumors. Although this could be due to inadequate screening strategies, the precise reason for this observation is not clear. Mayo Clinic researchers compared survival of patients with prevalent EAC with and without synchronous Barrett esophagus (BE) with intestinal metaplasia (IM) at the time of EAC diagnosis. Clinical data were studied using Cox proportional hazards regression to evaluate the effect of synchronous BE-IM on EAC survival independent of age, sex, TNM stage, and tumor location. Researchers analyzed data from a cohort of patients with EAC from the Mayo Clinic and a multicenter cohort from the United Kingdom. Two types of EAC can be characterized based on the presence or absence of BE. These findings could increase the understanding of the etiology of EAC and be used in management and prognosis of patients. The study was published in Gastroenterology.
Published to PubMed This Week
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- Pathological, Imaging and Genetic Characteristics Support the Existence of Distinct TDP-43 Types in Non-FTLD Brains
Acta Neuropathologica
- Molecular Signatures of Multiple Myeloma Progression through Single Cell RNA-Seq
Blood Cancer Journal
- Large Chromosomal Rearrangements Yield Biomarkers to Distinguish Low-Risk from Intermediate- and High-Risk Prostate Cancer
Mayo Clinic Proceedings
- Cost Efficacy of α-Galactosidase A Enzyme Screening for Fabry Disease
Mayo Clinic Proceedings - Cancer Susceptibility Gene Mutations in Type I and II Endometrial Cancer
Gynecologic Oncology
- Relationship of Ganciclovir Therapeutic Drug Monitoring with Clinical Efficacy and Patient Safety
Antimicrobial Agents and Chemotherapy
- Pro-fibrotic Effects of IL-17A and Elevated IL-17RA in IPF and RA-ILD Support a Direct Role for IL-17A/IL-17RA in Human Fibrotic Interstitial Lung Disease
American Journal of Physiology-Lung Cellular and Molecular Physiology - Cigarette Smoking Is Associated with Adverse Pathological Response and Increased Disease Recurrence amongst Patients with Muscle-Invasive Bladder Cancer Treated with Cisplatin-Based Neoadjuvant Chemotherapy and Radical Cystectomy: A Single-Centre Experience
BJU International
- Proceedings from the Ice Hockey Summit III: Action on Concussion
Current Sports Medicine Reports - Androgen Mediation—and Antiandrogens Mitigation—of the Epidermal Growth Factor Receptor (EGFR) Inhibitor-Induced Rash: Results From a Pilot Randomized Trial and Small Translational Case Series
American Journal of Hospice and Palliative Medicine - Clinical Correlates, Prognostic Impact and Survival Outcomes in Chronic Myelomonocytic Leukemia Patients with the JAK2V617F Mutation
Haematologica
- Using Germline Variants to Estimate Glioma and Subtype Risks
Neuro-Oncology
- A Moldy Application of MALDI: MALDI-ToF Mass Spectrometry for Fungal Identification
Journal of Fungi
- Pathological, Imaging and Genetic Characteristics Support the Existence of Distinct TDP-43 Types in Non-FTLD Brains
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