Mayo Clinic Laboratory and Pathology Research Roundup: May 6

By Alyssa Frank • May 6, 2019

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The Research Roundup provides an overview of the past week’s research from Mayo Clinic Laboratories consultants, including featured abstracts and a complete list of published studies and reviews.

Featured Abstract

Cytogenetic Clonal Evolution in Myeloproliferative Neoplasms: Contexts and Prognostic Impact Among 648 Patients with Serial Bone Marrow Biopsies

Karyotype is diagnostically and prognostically essential in patients with myeloproliferative neoplasms (MPN); cytogenetic abnormalities occur in approximately a third of patients with primary myelofibrosis (PMF) and 5–20% of those with essential thrombocythemia (ET) or polycythemia vera (PV). “Abnormal” karyotype in PV and “unfavorable” or “very high risk (VHR)” karyotype in
PMF have been associated with inferior survival.

Published to PubMed This Week

• Cationic Carrier Peptide Enhances Cerebrovascular Targeting of Nanoparticles in Alzheimer's Disease Brain
  Nanomedicine: Nanotechnology, Biology, and Medicine
• Leiomyoma with KAT6B-KANSL1 Fusion: Case Report of a Rapidly Enlarging Uterine Mass in a Postmenopausal Woman
  Diagnostic Pathology
• Accuracy of Self-Reported Cancer Treatment Data in Young Breast Cancer Survivors
  Journal of Patient-Reported Outcomes
• Mitochondrial Cerebellar Ataxia, Renal Failure, Neuropathy, and Encephalopathy (MCARNE)
  Neurology. Genetics.
• Early Podocyte Injury and Elevated Levels of Urinary Podocyte-Derived Extracellular Vesicles in Swine with Metabolic Syndrome: Role of Podocyte Mitochondria
  American Journal of Physiology. Renal Physiology.
• Endemic Bot Fly Larvae Infection in Northern New York State
  ID Cases
  

Alyssa Frank

Alyssa Frank is a Marketing Segment Manager at Mayo Clinic Laboratories. She leads marketing strategies for product management and specialty testing. Alyssa has worked at Mayo Clinic since 2015.