Mayo Clinic Laboratory and Pathology Research Roundup: July 1

By Samantha Rossi • July 1, 2019

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The research roundup provides an overview of the past week’s research from Mayo Clinic Laboratories consultants, including featured abstracts and a complete list of published studies and reviews.

Featured Abstract

PRMT1-mediated FLT3 arginine methylation promotes maintenance of FLT3-ITD+ Acute Myeloid Leukemia.

The presence of FLT3-ITD mutations in patients with acute myeloid leukemia (AML) is associated with poor clinical outcome. FLT3 tyrosine kinase inhibitors (TKIs), although effective in kinase ablation, do not eliminate primitive FLT3-ITD+ leukemia cells, which are potential sources of relapse. Thus understanding mechanisms underlying FLT3-ITD+ AML cell persistence is essential to devise future AML therapies. Here, we show that expression of PRMT1, the primary type I arginine methyltransferase, significantly increases in AML cells relative to normal hematopoietic cells.

Published to PubMed This Week

• Microglia Are Indispensable for Synaptic Plasticity in the Spinal Dorsal Horn and Chronic Pain
  Cell Reports
• Spontaneous murine tumors in the development of patient-derived xenografts: a potential pitfall
  Oncotarget
• Type Iγ phosphatidylinositol phosphate kinase dependent cell migration and invasion are dispensable for tumor metastasis
  American Journal of Cancer Research
• Comparison of high-sensitivity cardiac troponin I and T for the prediction of cardiac complications after non-cardiac surgery
  American Heart Journal
• Variability in gene-based knowledge impacts variant classification: an analysis of FBN1 missense variants in ClinVar
  European Journal of Human Genetics
• Heme Oxygenase-2 Protects Against Ischemic Acute Kidney Injury: The Influence of Age and Sex
  Anticancer Journal of Physiology, Renal Physiology
• Prognostic subclass of intrahepatic cholangiocarcinoma by integrative molecular-clinical analysis and potential targeted approach
  Hepatology International
• Loss of SDHB protein expression by immunohistochemistry distinguishes pulmonary chondromas from hamartomas
  Histopathology
• Implementation of a patient blood management program in hematopoietic stem cell transplantation
  Transfusion
• Algorithmic evaluation of hereditary erythrocytosis: Pathways and caveats
  International Journal of Laboratory Hematology
• Diagnosis of Fungal Infections: A Systematic Review and Meta-Analysis Supporting ATS Clinical Practice Guideline
  Annals of the American Thoracic Society
• Variable global distribution of cell-of-origin from the ROBUST phase 3 study in diffuse large B-cell lymphoma
  Haematologica
• Facial nerve venous malformation: A radiologic and histopathologic review of 11 cases
  Laryngoscope Investigative Otolaryngology
• Hydrogen-Peroxide-Generating Electrochemical Scaffold Eradicates Methicillin-Resistant Staphylococcus aureus Biofilms
  Global Challenges

Samantha Rossi

Samantha Rossi is a Digital Marketing Manager at Mayo Clinic Laboratories. She supports marketing strategies for product management and specialty testing. Samantha has worked at Mayo Clinic since 2019.