Mayo Clinic Laboratory and Pathology Research Roundup: May 25

By Samantha Rossi • May 25, 2020

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The research roundup provides an overview of the past week’s research from Mayo Clinic Laboratories consultants, including featured abstracts and a complete list of published studies and reviews.

Featured Abstract

Contribution of Germline Predisposition Gene Mutations to Breast Cancer Risk in African American Women.

The risks of breast cancer in African American (AA) women associated with inherited mutations in breast cancer predisposition genes are not well defined. Thus, whether multigene germline hereditary cancer testing panels are applicable to this population is unknown. We assessed associations between mutations in panel-based genes and breast cancer risk in 5054 AA women with breast cancer and 4993 unaffected AA women drawn from 10 epidemiologic studies. Via Journal of National Cancer Institution.

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Published to PubMed This Week

• Association Between Tumor Necrosis Factor Inhibitor Exposure and Inflammatory Central Nervous System Events.
  JAMA Neurology
• ST-segment Elevation, Myocardial Injury, and Suspected or Confirmed COVID-19 Patients: Diagnostic and Treatment Uncertainties.
  Mayo Clinic Proceedings
• Xanthogranulomatous Epithelial Tumor: Report of 6 Cases of a Novel, Potentially Deceptive Lesion with a Predilection for Young Women.
  Modern Pathology
• T-Cell Clones of Uncertain Significance are Highly Prevalent and Show Close Resemblance to T-Cell Large Granular Lymphocytic Leukemia. Implications for Laboratory Diagnostics.
  Modern Pathology
• Implications and Outcomes of MRD-Negative Multiple Myeloma Patients with Immunofixation Positivity.
  American Journal of Hematology
• Enhancing the R-ISS Classification of Newly Diagnosed Multiple Myeloma by Quantifying Circulating Clonal Plasma Cells.
  American Journal of Hematology
• Clinical and Radiographic Adverse Events after Gamma Knife Radiosurgery for Brainstem Lesions: A Dosimetric Analysis.
  Radiotherapy for Oncology
• Timing and Distribution of Early Renal Cell Carcinoma Recurrences Stratified by Pathological Nodal Status in M0 Patients at the time of Nephrectomy.
  International Journal of Urology
• Detection of Cryptic CCND1 Rearrangements in Mantle Cell Lymphoma by Next Generation Sequencing.
  Annals of Diagnostic Pathology
• Well-Differentiated/Dedifferentiated Liposarcoma Arising in the Upper Aerodigestive Tract: 8 Cases Mimicking Non-adipocytic Lesions.
  Head and Neck Pathology

Samantha Rossi

Samantha Rossi is a Digital Marketing Manager at Mayo Clinic Laboratories. She supports marketing strategies for product management and specialty testing. Samantha has worked at Mayo Clinic since 2019.