Mayo Clinic Laboratory and Pathology Research Roundup: June 22
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The research roundup provides an overview of the past week’s research from Mayo Clinic Laboratories consultants, including featured abstracts and a complete list of published studies and reviews.
Featured Abstract
Early safety indicators of COVID-19 convalescent plasma in 5,000 patients.
Convalescent plasma is the only antibody-based therapy currently available for patients with coronavirus disease 2019 (COVID-19). It has robust historical precedence and sound biological plausibility. Although promising, convalescent plasma has not yet been shown to be safe as a treatment for COVID-19.METHODSThus, we analyzed key safety metrics after transfusion of ABO-compatible human COVID-19 convalescent plasma in 5000 hospitalized adults with severe or life-threatening COVID-19, with 66% in the intensive care unit, as part of the US FDA expanded access program for COVID-19 convalescent plasma. Via The Journal of Clinical Investigation.
Published to PubMed This Week
- Myocardial Injury in Severe COVID-19 Infection.
European Heart Journal - Clinical Reasoning: Multifocal Neuropathies in a Patient with Waldenstrom Macroglobulinemia and Prior Borreliosis.
Neurology - Neoadjuvant Immunotherapy for Non-Small Cell Lung Cancer - Current Concepts and Future Approaches.
Journal of Thoracic Oncology - Semaphorin 3B-Associated Membranous Nephropathy is a Distinct Type of Disease Predominantly Present in Pediatric Patients.
Kidney International - ST-segment Elevation, Myocardial Injury, and Suspected or Confirmed COVID-19 Patients: Diagnostic and Treatment Uncertainties.
Mayo Clinic Proceedings - An International Phase 2 Study of Pazopanib in Progressive and Metastatic Thyroglobulin Antibody Negative Radioactive Iodine Refractory Differentiated Thyroid Cancer.
Thyroid - Acute Symptomatic Seizures Secondary to Autoimmune Encephalitis and Autoimmune-Associated Epilepsy: Conceptual Definitions.
Epilepsia - Laboratory Monitoring of Patients with Hereditary Tyrosinemia Type I.
Molecular Genetics and Metabolism - Potential Differences Between Monolingual and Bilingual Patients in Approach and Outcome After Awake Brain Surgery.
Journal of Neurooncology - Double Seropositivity for AChR and MuSK Autoantibodies in Myasthenia Gravis.
Neuromuscular Disorder - Concordance Between Predicted HLA Type Using Next Generation Sequencing Data Generated for Non-HLA Purposes and Clinical HLA Type.
Human Immunology - Pancreatic Endocrine Heterotopia Involving Meckel's Diverticulum: A Potential Mimic of Neuroendocrine Tumor.
International Journal of Surgical Pathology - Treatment Effectiveness and Medication Use Reduction for Older Adults in Interdisciplinary Pain Rehabilitation.
Mayo Clinic Proceedings - Improved Recognition of 25-Hydroxyvitamin D2 by 2 Automated Immunoassays.
Journal of Applied Laboratory Medicine - A Review of Cardiac Complications in Coronavirus Disease 2019.
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