Mayo Clinic Laboratory and Pathology Research Roundup: July 6

By Samantha Rossi • July 6, 2020

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The research roundup provides an overview of the past week’s research from Mayo Clinic Laboratories consultants, including featured abstracts and a complete list of published studies and reviews.

Featured Abstract

N-glycosylation of Monoclonal Light Chains on Routine MASS-FIX Testing is A Risk Factor for MGUS Progression.

Our group previously demonstrated that M-protein light chain (LC) glycosylation can be detected on routine MASS-FIX testing. Glycosylation is increased in patients with immunoglobulin LC amyloidosis (AL) and rarely changes over the course of a patient's lifetime. To determine the rates of progression to AL and other plasma cell disorders (PCDs), we used residual serum samples from the Olmsted monoclonal gammopathy of undetermined significance (MGUS) screening cohort. Four-hundred and fourteen patients with known MGUS were tested by MASS-FIX, and 25 (6%) were found to have glycosylated LCs. With a median follow-up of surviving patients of 22.2 years, the 20-year progression rates to a malignant PCD were 67% (95% CI 29%, 84%) and 13% (95% CI 9%, 18%) for patients with and without glycosylated LCs, respectively. The risk of progression was independent of Mayo MGUS risk score. The respective rates of progression to AL at 20 years were 21% (95% CI 0.0%, 38%) and 3% (95% CI 0.6%, 5.5%). In summary, monoclonal LC glycosylation is a potent risk factor for progression to AL, myeloma, and other PCDs, an observation which could lead to earlier diagnoses and potentially reduced morbidity and mortality. Via Leukemia.

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Published to PubMed This Week

• Sialic Acid Bearing Paraproteins Are Implicated In Heparin-Like Coagulopathy In Myeloma Patients.
  Blood
• CSF biomarkers in Olmsted County: Evidence of 2 Subclasses and Associations with Demographics.
  Neurology
• Unbiased Metagenomics - A New Tool for Detecting Early Lyme Disease?
  Clinical Infectious Disease
• Speaking a Common Language: Introduction to a Standard Terminology for the Bicuspid Aortic Valve and its Aortopathy.
  Progress in Cardiovascular Disease
• Neuroendocrine Cells Are Commonly Absent in the Intestinal Crypts in Autoimmune Enteropathy.
  American Journal of Clinical Pathology
• Correction for Mathison and Pritt, "Medical Parasitology Taxonomy Update, 2016-2017".
  Journal of Clinical Microbiology
• Use of Diffusion-Weighted Imaging to Distinguish Seizure-Related Change from Limbic Encephalitis.
  Journal of Neurology
• Utility of Immunohistochemistry for MUC4 and GATA3 to Aid in the Distinction of Pleural Sarcomatoid Mesothelioma From Pulmonary Sarcomatoid Carcinoma.
  Archives in Pathology Laboratory Medicine
• The 2019 Genitourinary Pathology Society (GUPS) White Paper on Contemporary Grading of Prostate Cancer.
  Archives in Pathology Laboratory Medicine
• Fifty Years of Impact on Liver Pathology: A History of the Gnomes.
  Virchows Archives
• Ki-67 "Hot Spot" Digital Analysis is Useful in the Distinction of Hepatic Adenomas and Well-Differentiated Hepatocellular Carcinomas.
  Virchows Archives
• The ABC's of Disaster Management: Managing Apheresis Operations During the SARS-CoV-2 Pandemic.
  Journal of Clinical Apheresis
• Diffuse Neuritis Ossificans of the Brachial Plexus: Case Report and Review of the Literature.
  World of Neurology
• Impact of Diverse Data Sources on Computational Phenotyping.
  Frontiers in Genetics
• The Tsar's Doctor: The Selfless and Devoted Life of Dr Eugene Botkin.
  Journal of Medical Biography

Samantha Rossi

Samantha Rossi is a Digital Marketing Manager at Mayo Clinic Laboratories. She supports marketing strategies for product management and specialty testing. Samantha has worked at Mayo Clinic since 2019.