Mayo Clinic Laboratory and Pathology Research Roundup: July 20

By Samantha Rossi • July 20, 2020

Share this:

The research roundup provides an overview of the past week’s research from Mayo Clinic Laboratories consultants, including featured abstracts and a complete list of published studies and reviews.

Featured Abstract

Cardiac Troponin for the Diagnosis and Risk-Stratification of Myocardial Injury in COVID-19

Increases in cardiac troponin (cTn) indicative of myocardial injury are common in patients with COVID-19 and associated with adverse outcomes such as arrhythmias and death. These increases are more likely to occur in those with chronic cardiovascular conditions and in those with severe COVID-19 presentations. The increased inflammatory, prothrombotic, and procoagulant responses following SARS-CoV-2 infection increase the risk for acute nonischemic myocardial injury and acute myocardial infarction, particularly type 2 myocardial infarction because of respiratory failure with hypoxia and hemodynamic instability in critically ill patients. Myocarditis, stress cardiomyopathy, acute heart failure, and direct injury from SARS-CoV-2 are important etiologies, but primary non-cardiac conditions such as pulmonary embolism, critical illness, and sepsis probably cause more of the myocardial injury. The structured use of serial cTn has the potential to facilitate risk stratification, help make decisions about when to use imaging, and inform stage categorization and disease phenotyping among hospitalized COVID-19 patients. Via Journal of American College of Cardiology.

Read more.

Published to PubMed This Week

• Low-Dose Testosterone Augmentation for Antidepressant-Resistant Major Depressive Disorder in Women: An 8-Week Randomized Placebo-Controlled Study.
  American Journal of Psychiatry
• Combined Fasting Serum C4 and Primary Bile Acids from a Single Stool Sample Diagnose Bile Acid Diarrhea.
  Gastroenterology
• Neuroimaging Correlates with Neuropathologic Schemes in Neurodegenerative Disease.
  Alzheimers and Dementia
• Low-Dose Testosterone Augmentation for Antidepressant-Resistant Major Depressive Disorder in Women: An 8-Week Randomized Placebo-Controlled Study.
  American Journal of Psychiatry
• Impact of Acquired Del(17p) in Multiple Myeloma.
  Blood Advances
• Mesenchymal Stem/Stromal Cells and Their Extracellular Vesicle Progeny Decrease Injury in Post-Stenotic Swine Kidney Through Different Mechanisms.
  Stem Cells and Development
• Effect of Trapeziectomy on Carpal Stability.
  Hand
• Differences in Cytotoxicity of Lidocaine, Ropivacaine, Bupivacaine on the Viability and Metabolic Activity of Human Adipose-Derived Mesenchymal Stem Cells.
  American Journal of Physical Medicine and Rehabilitation
• Progress Towards Developing a Rapid Triage/Referral Test for Tuberculosis.
  Clinical Chemistry

Samantha Rossi

Samantha Rossi is a Digital Marketing Manager at Mayo Clinic Laboratories. She supports marketing strategies for product management and specialty testing. Samantha has worked at Mayo Clinic since 2019.