Mayo Clinic Laboratory and Pathology Research Roundup: October 5
The research roundup provides an overview of the past week’s research from Mayo Clinic Laboratories consultants, including featured abstracts and a complete list of published studies and reviews.
Pathological Features of COVID-19-Associated Myocardial Injury: A Multicentre Cardiovascular Pathology Study.
In an international multicentre study, cardiac tissue from the autopsies of 21 consecutive COVID-19 patients was assessed by cardiovascular pathologists. The presence of myocarditis, as defined by the presence of multiple foci of inflammation with associated myocyte injury, was determined, and the inflammatory cell composition analysed by immunohistochemistry. Other forms of acute myocyte injury and inflammation were also described, as well as coronary artery, endocardium, and pericardium involvement. Lymphocytic myocarditis was present in 3 (14%) of the cases. In two of these cases, the T lymphocytes were CD4 predominant and in one case the T lymphocytes were CD8 predominant. Increased interstitial macrophage infiltration was present in 18 (86%) of the cases. A mild pericarditis was present in four cases. Acute myocyte injury in the right ventricle, most probably due to strain/overload, was present in four cases. There was a non-significant trend toward higher serum troponin levels in the patients with myocarditis compared with those without myocarditis. Disrupted coronary artery plaques, coronary artery aneurysms, and large pulmonary emboli were not identified. Via European Heart Journal.
Published to PubMed This Week
- An Urgent Need for Studies of the Late Effects of SARS-CoV-2 on the Cardiovascular System.
- Intracranial Myxoid Mesenchymal Tumor/Myxoid Subtype Angiomatous Fibrous Histiocytoma: Diagnostic and Prognostic Challenges.
- Comparison of Agar Dilution to Broth Microdilution for Testing in vitro Activity of Cefiderocol against Gram-negative Bacilli.
Journal of Clinical Microbiology
- Novel Biomarkers and Age-Related Metabolite Correlations in Plasma and Dried Blood Spots from Patients with Succinic Semialdehyde Dehydrogenase Deficiency.
Orphanet Journal of Rare Disease
- Human Papillomavirus Oropharynx Carcinoma: Aggressive De-Escalation of Adjuvant Therapy.
Head and Neck
- Analysis and Impact of a Multidisciplinary Lymphoma Virtual Tumor Board.
Leukemia and Lymphoma
- Measuring the Contribution of Lp(a) Cholesterol Towards LDL-C Interpretation.
- Continuous Glucose Monitors and Automated Insulin Dosing Systems in the Hospital Consensus Guideline.
Journal of Diabetes and Science Technology