Alpha-gal testing [A Test in Focus]
Galactose-alpha 1,3 galactose IgE — a serum test for IgE antibodies against alpha-gal —is a new FDA-approved test that provides an indication of potential allergic response. In this "Test in Focus" episode of the "Answers From the Lab" podcast, Joshua Bornhorst, Ph.D., associate director of Mayo Clinic's Clinical Immunoassay Lab, explains how humans can develop an allergy to the alpha-gal molecule, and he describes the allergen antibody test that can be used to detect it.
"In this immunocap assay, specific IGA antibodies from the patient's serum react with the allergen of interest, alpha-gal, which is covalently coupled to a solid matrix, and the binding is subsequently detected in the quantitative faction," Dr. Bornhorst says.
In the podcast, Dr. Bornhorst also reviews other tests that should be used in conjunction with alpha-gal testing to accurately identify the scope and underlying cause of the allergy.
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As an aid in diagnosis of an IgE mediated hypersensitivity allergy to non-primate mammalian red meat or meat-derived products such as beef, pork, venison, and meat-derived products (e.g. gelatin).
Preferred: Red top
Acceptable: Serum gel
Specimen Volume: 0.5 mL for every 5 allergens requested
Monday through Friday; 9 a.m.-8 p.m.
Saturday; 8 a.m.-3 p.m.
Same day/1 day