Mayo Clinic laboratory and pathology research roundup: December 7

By Samantha Rossi • December 7, 2020

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The research roundup provides an overview of the past week’s research from Mayo Clinic Laboratories consultants, including featured abstracts and a complete list of published studies and reviews.

Featured Abstract

Iron Heterogeneity in Early Active Multiple Sclerosis Lesions.

Multiple sclerosis (MS) is a heterogeneous inflammatory demyelinating disease. Iron distribution is altered in MS patients' brains suggesting iron liberation within active lesions amplifies demyelination and neurodegeneration. Whether the amount and distribution of iron are similar or different among different MS immunopatterns is currently unknown. Via Annals in Neurology

Read more.

Published to PubMed This Week

• Alpha 1-Antichymotrypsin Contributes to Stem Cell Characteristics and Enhances Tumorigenicity of Glioblastoma.
  Neuro-Oncology
• N-Glycosylation of Monoclonal Light Chains on Routine MASS-FIX Testing is a Risk Factor for MGUS Progression.
  Leukemia
• The Dynamic and Multifaceted Nature of Cardiovascular Disease and Using Genetic Testing to Inform Clinical Care: An International Perspective.
  Clinical Chemistry
• Recruitment Strategy for Potential COVID-19 Convalescent Plasma Donors.
  Mayo Clinic Proceedings
• Recurrence of DNAJB9-Positive Fibrillary Glomerulonephritis After Kidney Transplantation: A Case Series.
  American Journal of Kidney Disease
• Targeting the RhoGEF βPIX/COOL-1 in Glioblastoma: Proof of Concept Studies.
  Cancers
• Direct Inpatient Medical Costs of Operative Treatment of Periprosthetic Hip and Knee Infections Are Twofold Higher Than Those of Aseptic Revisions.
  Journal of Bone and Joint Surgery
• Unexpected Obesity, Rather than Tumorigenesis, in a Conditional Mouse Model of Mitochondrial Complex II Deficiency.
  FASEB Journal
• Update on SWI/SNF-Related Gynecologic Mesenchymal Neoplasms: SMARCA4-Deficient Uterine Sarcoma and SMARCB1-Deficient Vulvar Neoplasms.
  Genes and Chromosomes Cancer
• A rare Manifestation of CMV Disease in a Kidney Transplant Recipient.
  Transplants Infectious Disease

Samantha Rossi

Samantha Rossi is a Digital Marketing Manager at Mayo Clinic Laboratories. She supports marketing strategies for product management and specialty testing. Samantha has worked at Mayo Clinic since 2019.