Mayo Clinic laboratory and pathology research roundup: January 11
Share this:
The research roundup provides an overview of the past week’s research from Mayo Clinic Laboratories consultants, including featured abstracts and a complete list of published studies and reviews.
Featured Abstract
Changing paradigms in diagnosis and treatment of monoclonal gammopathy of undetermined significance (MGUS) and smoldering multiple myeloma (SMM).
Multiple myeloma (MM) is a highly heterogenous disease that exists along a continuous disease spectrum starting with premalignant conditions monoclonal gammopathy of undetermined significance (MGUS) and smoldering multiple myeloma (SMM) that inevitably precede MM. Over the past two decades, significant progress has been made in the genetic characterization and risk stratification of precursor plasma cell disorders. Indeed, the clinical introduction of highly effective and well-tolerated drugs begs the question: would earlier therapeutic intervention with novel therapies in MGUS and SMM patients alter natural history, providing a potential curative option? In this review, we discuss the epidemiology of MGUS and SMM and current models for risk stratification that predict MGUS and SMM progression to MM. We further discuss genetic heterogeneity and clonal evolution in MM and the interplay between tumor cells and the bone marrow (BM) microenvironment. Finally, we provide an overview of the current recommendations for the management of MGUS and SMM and discuss the open controversies in the field in light of promising results from early intervention clinical trials. Via Leukemia
Published to PubMed This Week
- New 'Antigens' in Membranous Nephropathy.
Journal of American Society of Nephrology - The Rodger C. Haggitt Gastrointestinal Pathology Society at the 2020 United States and Canadian Academy of Pathology: A Mini-symposium.
American Journal of Surgical Pathology - Chromosomal Junction Detection from Whole Genome Sequencing on Formalin-fixed, Paraffin-embedded Tumors.
Journal of Molecular Diagnostics - Temporal Trends, Predictors, and Outcomes of Acute Ischemic Stroke in Acute Myocardial Infarction in the United States.
Journal of the American Heart Association - An Integrated HOCl-Producing E-Scaffold Is Active Against Monomicrobial and Polymicrobial Biofilms.
Antimicrobial Agents and Chemotherapy - Association of sleep-disordered breathing and wound healing in patients with diabetic foot ulcers.
Journal of Clinical Sleep Medicine - Association of mammographic density measures and breast cancer "intrinsic" molecular subtypes.
Breast Cancer Research and Treatment - A clinical calculator to predict disease outcomes in women with triple-negative breast cancer.
Breast Cancer Research and Treatment - Hypochlorous acid-generating electrochemical scaffold eliminates Candida albicans biofilms.
Journal of Applied Microbiology - Hepatocellular Carcinoma: Making Sense of Morphological Heterogeneity, Growth Patterns, and Subtypes.
Human Pathology
