Mayo Clinic laboratory and pathology research roundup: February 15

By Samantha Rossi • February 15, 2021

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The research roundup provides an overview of the past week’s research from Mayo Clinic Laboratories consultants, including featured abstracts and a complete list of published studies and reviews.

Featured Abstract

Trans-ancestry genome-wide association meta-analysis of prostate cancer identifies new susceptibility loci and informs genetic risk prediction.

Prostate cancer is a highly heritable disease with large disparities in incidence rates across ancestry populations. We conducted a multiancestry meta-analysis of prostate cancer genome-wide association studies (107,247 cases and 127,006 controls) and identified 86 new genetic risk variants independently associated with prostate cancer risk, bringing the total to 269 known risk variants. The top genetic risk score (GRS) decile was associated with odds ratios that ranged from 5.06 (95% confidence interval (CI), 4.84-5.29) for men of European ancestry to 3.74 (95% CI, 3.36-4.17) for men of African ancestry. Men of African ancestry were estimated to have a mean GRS that was 2.18-times higher (95% CI, 2.14-2.22), and men of East Asian ancestry 0.73-times lower (95% CI, 0.71-0.76), than men of European ancestry. These findings support the role of germline variation contributing to population differences in prostate cancer risk, with the GRS offering an approach for personalized risk prediction. Via Nature Genetics

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Published to PubMed This Week

• Addition of lenalidomide to R-CHOP improves outcomes in newly diagnosed diffuse large b-cell lymphoma in a randomized phase II US Intergroup Study ECOG-ACRIN E1412.
  Journal of Clinical Oncology
• Paraneoplastic myeloneuropathies: Clinical, oncologic, and serologic accompaniments.
  Neurology
• Clinical spectrum of high-titre GAD65 antibodies.
  Journal of Neurology, Neurosurgery, and Psychiatry
• Mass spectrometry for the evaluation of monoclonal proteins in multiple myeloma and related disorders: an International Myeloma Working Group Mass Spectrometry Committee Report.
  Blood Cancer Journal
• Non-neutralizing antibodies and limitations of serologic testing for severe acute respiratory syndrome coronavirus 2 in patients receiving immunoglobulin replacement products.
  Annals of Allergy, Asthma, and Immunology
• Ubiquitin-specific protease 6 functions as a tumor suppressor in Ewing Sarcoma through immune activation.
  Cancer Research
• Myeloid malignancies with 5q and 7q deletions are associated with extreme genomic complexity, biallelic TP53 variants, and very poor prognosis.
  Blood Cancer Journal
• Elevated rate of HLA antibodies in male COVID-19 convalescent plasma donors: A risk factor for transfusion-related acute lung injury.
  Mayo Clinic Proceedings
• Pheochromocytoma in multiple endocrine neoplasia type 2.
  Mayo Clinic Proceedings
• Brain ischemic injury in COVID-19-infected patients: a series of 10 post-mortem cases.
  Brain Pathology

Samantha Rossi

Samantha Rossi is a Digital Marketing Manager at Mayo Clinic Laboratories. She supports marketing strategies for product management and specialty testing. Samantha has worked at Mayo Clinic since 2019.