Mayo Clinic laboratory and pathology research roundup: March 9

By Samantha Rossi • March 9, 2021

Share this:

The research roundup provides an overview of the past week’s research from Mayo Clinic Laboratories consultants, including featured abstracts and a complete list of published studies and reviews.

Featured Abstract

Management of patients with giant cell myocarditis: JACC review topic of the week.

Giant cell myocarditis is a rare, often rapidly progressive and potentially fatal, disease due to T-cell lymphocyte-mediated inflammation of the myocardium that typically affects young and middle-aged adults. Frequently, the disease course is marked by acute heart failure, cardiogenic shock, intractable ventricular arrhythmias, and/or heart block. Diagnosis is often difficult due to its varied clinical presentation and overlap with other cardiovascular conditions. Although cardiac biomarkers and multimodality imaging are often used as initial diagnostic tests, endomyocardial biopsy is required for definitive diagnosis. Combination immunosuppressive therapy, along with guideline-directed medical therapy, has led to a paradigm shift in the management of giant cell myocarditis resulting in an improvement in overall and transplant-free survival. Early diagnosis and prompt management can decrease the risk of transplantation or death, which remain common in patients who present with cardiogenic shock. Via Journal of American College of Cardiology

Read more.

Published to PubMed This Week

• Landscape of RAS pathway mutations in patients with myelodysplastic syndrome/myeloproliferative neoplasm overlap syndromes: a study of 461 molecularly annotated patients.
  Leukemia
• 1α,25-Dihydroxyvitamin D₃ encapsulated in nanoparticles prevents venous neointimal hyperplasia and stenosis in porcine arteriovenous fistulas.
  American Journal of Society of Nephrology
• Venetoclax treatment of patients with relapsed T-cell prolymphocytic leukemia.
  Blood Cancer Journal
• Treatment outcome of clonal cytopenias of undetermined significance: a single-institution retrospective study.
  Blood Cancer Journal
• Elevated rate of HLA antibodies in male COVID-19 convalescent plasma donors: A risk factor for transfusion-related acute lung injury.
  Mayo Clinic Proceedings
• Aspirin and other nonsteroidal anti-inflammatory drugs, statins, and risk of non-Hodgkin lymphoma.
  International Journal of Cancer
• Detection of tick-borne bacteria from whole blood using 16S ribosomal RNA gene PCR followed by next-generation sequencing.
  Journal of Clinical Microbiology
• [Corrigendum] Silencing of type Iγ phosphatidylinositol phosphate kinase suppresses ovarian cancer cell proliferation, migration and invasion.
  Oncology Reports
• Age-related histologic features of the sinoatrial node from normal human hearts during the first 10 decades of life: A study of 200 cases.
  Cardiovascular Pathology
• Collision of craniopharyngioma and pituitary adenoma: comprehensive review of an extremely rare sellar condition.
  World Neurosurgery

Samantha Rossi

Samantha Rossi is a Digital Marketing Manager at Mayo Clinic Laboratories. She supports marketing strategies for product management and specialty testing. Samantha has worked at Mayo Clinic since 2019.