Mayo Clinic laboratory and pathology research roundup: April 6
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The research roundup provides an overview of the past week’s research from Mayo Clinic Laboratories consultants, including featured abstracts and a complete list of published studies and reviews.
Featured Abstract
Convalescent plasma antibody levels and the risk of death from Covid-19.
In a retrospective study based on a U.S. national registry, we determined the anti-SARS-CoV-2 IgG antibody levels in convalescent plasma used to treat hospitalized adults with Covid-19. The primary outcome was death within 30 days after plasma transfusion. Patients who were enrolled through July 4, 2020, and for whom data on anti-SARS-CoV-2 antibody levels in plasma transfusions and on 30-day mortality were available were included in the analysis. Via New England Journal of Medicine.
Published to PubMed This Week
- Mutations in BRCA1/2 and other panel genes in patients with metastatic breast cancer -association with patient and disease characteristics and effect on prognosis.
Journal of Clinical Oncology - Kidney injury and disease in patients with haematological malignancies.
Nature Reviews. Nephrology - Strong functional data for pathogenicity or neutrality classify BRCA2 DNA-binding-domain variants of uncertain significance.
American Journal of Human Genetics - Mutated SPOP E3 ligase promotes 17βHSD4 protein degradation to drive androgenesis and prostate cancer progression.
Cancer Research - Immunofluorescence staining for immunoglobulin heavy chain/light chain on kidney biopsies is a valuable ancillary technique for the diagnosis of monoclonal gammopathy-associated kidney diseases.
Kidney International - Commentary on unexpected presence of an unusual opioid in a patient with chronic pain.
Clinical Chemistry - Hypomagnesemia at the time of autologous stem cell transplantation for patients with diffuse large B-cell lymphoma is associated with an increased risk of failure.
Blood Cancer Journal - Musicogenic epilepsy: Expanding the spectrum of glutamic acid decarboxylase 65 neurological autoimmunity.
Epilepsia - Anticipatory human subthalamic area beta-band power responses to dissociable tastes correlate with weight gain.
Neurobiology Disease - Reactive eosinophil proliferations in tissue and the lymphocytic variant of hypereosinophilic syndrome.
American Journal of Clinical Pathology
