Mayo Clinic laboratory and pathology research roundup: May 25

By Samantha Rossi • May 25, 2021

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The research roundup provides an overview of the past week’s research from Mayo Clinic Laboratories consultants, including featured abstracts and a complete list of published studies and reviews.

Featured Abstract

RAS mutations drive proliferative chronic myelomonocytic leukemia via a KMT2A-PLK1 axis.

Proliferative chronic myelomonocytic leukemia (pCMML), an aggressive CMML subtype, is associated with dismal outcomes. RAS pathway mutations, mainly NRAS^G12D, define the pCMML phenotype as demonstrated by our exome sequencing, progenitor colony assays and a Vav-Cre-Nras^G12D mouse model. Via Nature Communications.

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Published to PubMed This Week

• Monoclonal gammopathy of renal significance.
  New England Journal of Medicine
• The elevated high-sensitivity cardiac troponin t pilot: Diagnoses and outcomes.
  Mayo Clinic Proceedings
• Prevalence of SARS-CoV-2 antibodies in a Multistate Academic Medical Center.
  Mayo Clinic Proceedings
• Clinical correlates and prognostic impact of clonal hematopoiesis in multiple myeloma patients receiving post-autologous stem cell transplantation lenalidomide maintenance therapy.
  American Journal of Hematology
• Genetic and clinical studies of patients with increased multinucleated megakaryocytes in bone marrow as an isolated finding: A diagnostic pitfall for myelodysplastic syndrome.
  American Journal of Surgical Pathology
• Evaluation of Zn, Cu, and Se Levels in the North American Autism Spectrum Disorder Population.
  Frontiers in Molecular Neuroscience
• Clinical utility of next generation sequencing to detect IGH/IL3 rearrangements [t(5;14)(q31.1;q32.1)] in B-lymphoblastic leukemia/lymphoma.
  Annals of Diagnostic Pathology
• The role of surgical lung biopsy in the diagnosis of fibrotic interstitial lung disease: Perspective from the pulmonary fibrosis foundation.
  Annals of the American Thoracic Society
• Amyloid arthropathy in smoldering myeloma: Do not take it lightly.
  Leukemia Research and Reports
• A rare cause of apparent anuria after caesarean section: A case report.
  Cureus

Samantha Rossi

Samantha Rossi is a Digital Marketing Manager at Mayo Clinic Laboratories. She supports marketing strategies for product management and specialty testing. Samantha has worked at Mayo Clinic since 2019.