Mayo Clinic laboratory and pathology research roundup: June 15
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The research roundup provides an overview of the past week’s research from Mayo Clinic Laboratories consultants, including featured abstracts and a complete list of published studies and reviews.
Featured Abstract
Senolytics reduce coronavirus-related mortality in old mice.
The COVID-19 pandemic has revealed the pronounced vulnerability of the elderly and chronically-ill to SARS-CoV-2-induced morbidity and mortality. Cellular senescence contributes to inflammation, multiple chronic diseases, and age-related dysfunction, but effects on responses to viral infection are unclear. Here, we demonstrate that senescent cells (SnC) become hyper-inflammatory in response to pathogen-associated molecular patterns (PAMPs), including SARS-CoV-2 Spike protein-1, increasing expression of viral entry proteins and reducing anti-viral gene expression in non-SnCs through a paracrine mechanism. Via Science
Published to PubMed This Week
- Risk of breast cancer among carriers of pathogenic variants in breast cancer predisposition genes varies by polygenic risk score.
Journal of Clinical Oncology - Raising the bar for clinical cardiac troponin research studies and implementation science.
Circulation - A molecular pathology, neurobiology, biochemical, genetic and neuroimaging study of progressive apraxia of speech.
Nature Communications - Correction: MASS-FIX for the detection of monoclonal proteins and light chain N-glycosylation in routine clinical practice: a cross-sectional study of 6315 patients.
Blood Cancer Journal - Diagnostic challenges of focal nodular hyperplasia: Interobserver variability, accuracy, and the utility of glutamine synthetase immunohistochemistry.
Histopathology - Primary renal well-differentiated neuroendocrine tumor (Carcinoid) in a horseshoe kidney.
Mayo Clinic Proceedings - Treatment of AL Amyloidosis: Mayo stratification of myeloma and risk-adapted therapy (mSMART) consensus statement 2020 update.
Mayo Clinic Proceedings - Group III phospholipase A2 downregulation attenuated survival and metastasis in ovarian cancer and promotes chemo-sensitization.
Journal of Experimental and Clinical Cancer Research - Comparative transcriptomic analysis of staphylococcus aureus associated with periprosthetic joint infection under in vivo and in vitro conditions.
Journal of Molecular Diagnosis - Synovial fluid α defensin has comparable accuracy to synovial fluid white blood cell count and polymorphonuclear percentage for periprosthetic joint infection diagnosis.
Bone and Joint Journal
