Mayo Clinic laboratory and pathology research roundup: June 29
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The research roundup provides an overview of the past week’s research from Mayo Clinic Laboratories consultants, including featured abstracts and a complete list of published studies and reviews.
Featured Abstract
MAP3K7-IKK inflammatory signaling modulates AR protein degradation and prostate cancer progression.
Androgen receptor (AR) is a major survival factor for prostate cancer (PCa). Inflammation is implicated in many cancer types including PCa. Activation of MAP3K7 (also termed TAK1) and downstream IκB kinase β (IKKβ) by pro-inflammatory cytokines such as TNFα stimulates NF-κB survival pathways. Paradoxically, MAP3K7 is often deleted in human PCa. Here we demonstrate that AR protein expression is lower in inflammatory tumor areas compared to non-inflammatory tissues in PCa patients. Via Cancer Research
Published to PubMed This Week
- Renal neoplasia in tuberous sclerosis: A study of 41 patients.
Mayo Clinic Proceedings - Treatment of AL amyloidosis: Mayo stratification of myeloma and risk-adapted therapy (mSMART) consensus statement 2020 update.
Mayo Clinic Proceedings - Primary renal well-differentiated neuroendocrine tumor (carcinoid) in a horseshoe kidney.
Mayo Clinic Proceedings - Pediatric hepatocellular adenomas: The influence of age and syndrome on subtype.
American Journal of Surgical Pathology - IA bodybuilder with dyspnea and hypercalcemia.
American Journal Medicine - Activity of lysin CF-296 alone and in addition to daptomycin in a rat model of experimental methicillin-resistant staphylococcus aureus osteomyelitis.
Antimicrobial Agents and Chemotherapy - Practical development and operationalization of a 12-hour hospital census prediction algorithm.
JAMIA - Effects of the ABCB1 c.3435C>T (rs1045642) polymorphism on heat pain perception in opioid-free adults with chronic pain.
Anesthesia and Analgesia - Association of mammographic density measures and breast cancer "intrinsic" molecular subtypes.
Breast Cancer Research and Treatment - A systematic review supporting the society for vascular surgery guidelines on the management of carotid artery disease.
Journal of Vascular Surgery
