Mayo Clinic laboratory and pathology research roundup: July 6

The research roundup provides an overview of the past week’s research from Mayo Clinic Laboratories consultants, including featured abstracts and a complete list of published studies and reviews.
Featured Abstract
Ciliopathy protein HYLS1 coordinates the biogenesis and signaling of primary cilia by activating the ciliary lipid kinase PIPKIγ.
Mutation of ciliopathy protein HYLS1 causes the perinatal lethal hydrolethalus syndrome (HLS), yet the underlying molecular etiology and pathogenesis remain elusive. Here, we reveal unexpected mechanistic insights into the role of mammalian HYLS1 in regulating primary cilia. HYLS1 is recruited to the ciliary base via a direct interaction with the type Iγ phosphatidylinositol 4-phosphate [PI(4)P] 5-kinase (PIPKIγ). Via Science Advances
Published to PubMed This Week
- Leveraging existing and soon-to-be-available novel diagnostics for optimizing outpatient antibiotic stewardship in patients with respiratory tract infections.
Clinical Infectious Diseases - SARS-CoV-2 serologic assays dependent on dual-antigen binding demonstrate diverging kinetics relative to other antibody detection methods.
Journal of Clinical Microbiology - Extreme thrombocytosis in low-risk essential thrombocythemia: Retrospective review of vascular events and treatment strategies.
American Journal of Hematology - The prognostic significance of del6q23 in chronic lymphocytic leukemia.
American Journal of Hematology - SARS-CoV-2 serologic assays dependent on dual-antigen binding demonstrate diverging kinetics relative to other antibody detection methods.
Journal of Clinical Microbiology - Evaluation of MR elastography for prediction of lymph node metastasis in prostate cancer.
Abdomine Radiology - Uterine endometrial stromal tumors with limited infiltration and unusual patterns of smooth muscle/leiomyomatous differentiation: A report of 2 cases recapitulating leiomyoma variants.
International Journal of gynecological pathology - ESC study group on cardiac biomarkers of the association for acute cardioVascular care: A fond farewell at the retirement of CKMB.
European heart Journal - Immunofluorescence staining for immunoglobulin heavy chain/light chain on kidney biopsies is a valuable ancillary technique for the diagnosis of monoclonal gammopathy-associated kidney diseases.
Kidney International - A case of carbamazepine-induced acute pancreatitis: A rare etiology.
Cureus