Mayo Clinic Laboratory and pathology research roundup: August 3

By Chantell Canfield • August 3, 2021

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The research roundup provides an overview of the past week’s research from Mayo Clinic Laboratories consultants, including featured abstracts and a complete list of published studies and reviews.

Featured Abstract

Risk of Late-Onset Breast Cancer in Genetically Predisposed Women

The prevalence of germline pathogenic variants (PVs) in established breast cancer predisposition genes in women in the general population over age 65 years is not well-defined. However, testing guidelines suggest that women diagnosed with breast cancer over age 65 years might have < 2.5% likelihood of a PV in a high-penetrance gene. This study aimed to establish the frequency of PVs and remaining risks of breast cancer for each gene in women over age 65 years. Via Journal of Clinical Oncology

Read more.

Published to PubMed This Week

• Pathophysiology and biomarker potential of fatty acid ethyl ester elevation during alcoholic pancreatitis.
  Gastroenterology
• Comparison of CSF phosphorylated tau 181 and 217 for cognitive decline.
  Alzheimer's & Dementia
• Comparison of plasma phosphorylated tau species with amyloid and tau positron emission tomography, neurodegeneration, vascular pathology, and cognitive outcomes.
  JAMA Neurology
• Genomics accelerated isolation of a new stem rust avirulence gene-wheat resistance gene pair.
  Nature Plants
• Residency program directors' perceptions about the impact of the American board of anesthesiology's objective structured clinical examination.
  Journal of Clinical Anesthesia
• Association of concomitant bone resorption inhibitors with overall survival among patients with metastatic castration-resistant prostate cancer and bone metastases receiving abiraterone acetate with prednisone as first-line therapy.
  JAMA Network Open
• Altered speech patterns in subjects with post-traumatic headache due to mild traumatic brain injury.
  Journal of Headache and Pain
• Anaplastic thyroid carcinoma.
  Mayo Clinic Proceedings
• Antifibrotics modify B-Cell-induced fibroblast migration and activation in patients with idiopathic pulmonary fibrosis.
  American Journal of Respiratory Cell and Molecular Biology
• Reactive intralymphovascular immunoblastic proliferations mimicking aggressive lymphomas.
  The American Journal of Surgical Pathology

Chantell Canfield

Chantell Canfield is a web content coordinator for Mayo Clinic Laboratories. She began working for Mayo Clinic in 2021.