Mayo Clinic Laboratory and pathology research roundup: November 2
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The research roundup provides an overview of the past week’s research from Mayo Clinic Laboratories consultants, including featured abstracts and a complete list of published studies and reviews.
Featured Abstract
Phase II randomized trial of transoral surgery and low-dose intensity Modulated radiation therapy in resectable p16+ locally advanced oropharynx cancer: An ECOG-ACRIN cancer research group trial (E3311).
Definitive or postoperative chemoradiation (CRT) is curative for human papillomavirus-associated (HPV+) oropharynx cancer (OPC) but induces significant toxicity. As a deintensification strategy, we studied primary transoral surgery (TOS) and reduced postoperative radiation therapy (RT) in intermediate-risk HPV+ OPC.
Published to PubMed This Week
- Germline pathogenic variants in cancer predisposition genes among women with invasive lobular carcinoma of the breast.
Journal of Clinical Oncology - Asxl1loss cooperates with oncogenic Nras in mice to reprogram immune microenvironment and drive leukemic transformation.
Blood - The 2021 world health organization classification of tumors of the thymus and mediastinum: What's new in thymic epithelial, germ cell and mesenchymal tumors?
Journal of Thoracic Oncology - SPOP mutation induces DNA methylation via stabilizing GLP/G9a.
Nature Communications - Clinical and molecular correlates from a predominantly adult cohort of patients with short telomere lengths.
Blood Cancer Journal - Newly regenerated axons via scaffolds promote sub-lesional reorganization and motor recovery with epidural electrical stimulation.
NPJ Regenerative Medicine - A toolkit and framework for optimal laboratory evaluation of individuals with suspected primary immunodeficiency.
Journal of Allergy Clinical Immunology Practice - Genetic testing for inherited colorectal cancer and polyposis, 2021 revision: a technical standard of the American College of Medical Genetics and Genomics (ACMG).
Genetics in Medicine - Fatty acid synthase (FASN) regulates the mitochondrial priming of cancer cells.
Cell Death and Diseases - Hypochlorous acid-generating electrochemical catheter prototype for prevention of intraluminal infection.
Microbiology Spectrum
