Mayo Clinic Laboratory and pathology research roundup: November 2

By Chantell Canfield • November 2, 2021

Share this:

The research roundup provides an overview of the past week’s research from Mayo Clinic Laboratories consultants, including featured abstracts and a complete list of published studies and reviews.

Featured Abstract

Phase II randomized trial of transoral surgery and low-dose intensity Modulated radiation therapy in resectable p16+ locally advanced oropharynx cancer: An ECOG-ACRIN cancer research group trial (E3311).

Definitive or postoperative chemoradiation (CRT) is curative for human papillomavirus-associated (HPV+) oropharynx cancer (OPC) but induces significant toxicity. As a deintensification strategy, we studied primary transoral surgery (TOS) and reduced postoperative radiation therapy (RT) in intermediate-risk HPV+ OPC.

Read more.

Published to PubMed This Week

• Germline pathogenic variants in cancer predisposition genes among women with invasive lobular carcinoma of the breast.
  Journal of Clinical Oncology
• Asxl1loss cooperates with oncogenic Nras in mice to reprogram immune microenvironment and drive leukemic transformation.
  Blood
• The 2021 world health organization classification of tumors of the thymus and mediastinum: What's new in thymic epithelial, germ cell and mesenchymal tumors?
  Journal of Thoracic Oncology
• SPOP mutation induces DNA methylation via stabilizing GLP/G9a.
  Nature Communications
• Clinical and molecular correlates from a predominantly adult cohort of patients with short telomere lengths.
  Blood Cancer Journal
• Newly regenerated axons via scaffolds promote sub-lesional reorganization and motor recovery with epidural electrical stimulation.
  NPJ Regenerative Medicine
• A toolkit and framework for optimal laboratory evaluation of individuals with suspected primary immunodeficiency.
  Journal of Allergy Clinical Immunology Practice
• Genetic testing for inherited colorectal cancer and polyposis, 2021 revision: a technical standard of the American College of Medical Genetics and Genomics (ACMG).
  Genetics in Medicine
• Fatty acid synthase (FASN) regulates the mitochondrial priming of cancer cells.
  Cell Death and Diseases
• Hypochlorous acid-generating electrochemical catheter prototype for prevention of intraluminal infection.
  Microbiology Spectrum

Chantell Canfield

Chantell Canfield is a web content coordinator for Mayo Clinic Laboratories. She began working for Mayo Clinic in 2021.