Mayo Clinic Laboratory and pathology research roundup: December 21

By Chantell Canfield • December 21, 2021

Share this:

The research roundup provides an overview of the past week’s research from Mayo Clinic Laboratories consultants, including featured abstracts and a complete list of published studies and reviews.

Featured Abstract

Learning through a Pandemic: The current state of knowledge on COVID-19 and cancer.

The ongoing COVID-19 pandemic has left patients with current or past history of cancer facing disparate consequences at every stage of the cancer trajectory. This comprehensive review offers a landscape analysis of the current state of the literature on COVID-19 and cancer including the immune response to COVID-19, risk factors for severe disease, and impact of anticancer therapies. We also review the latest data on treatment of COVID-19 and vaccination safety and efficacy in patients with cancer, as well as impact of the pandemic on cancer care, including the urgent need for rapid evidence generation and real-world study designs.

Read more.

Published to PubMed This Week

• Outcomes in primary cutaneous diffuse large B-cell lymphoma, leg type.
  Hematological Oncology
• Implications of MYC rearrangements in newly diagnosed multiple myeloma.
  Clinical Cancer Research
• Sorbitol is a severity biomarker for PMM2-CDG with therapeutic implications.
  Annals of Neurology
• Interpretation and reporting of large regions of homozygosity and suspected consanguinity/uniparental disomy, 2021 revision: A technical standard of the American college of medical genetics and genomics (ACMG).
  Genetics in Medicine
• Risks of breast and ovarian cancer for women harboring pathogenic missense variants in BRCA1 and BRCA2 compared with those harboring protein truncating variants.
  Genetics in Medicine
• Identification of the minimal active soluble TREM2 sequence for modulating microglial phenotypes and amyloid pathology.
  Journal of Neuroinflammation
• Correction to: Myelodysplastic/myeloproliferative neoplasms-unclassifiable with isolated isochromosome 17q represents a distinct clinico-biologic subset: a multi-institutional collaborative study from the Bone Marrow Pathology Group.
  Modern Pathology
• Cardiopulmonary resuscitation training to improve out-of-hospital cardiac arrest survival: addressing potential health inequalities.
  European Journal of Preventive Cardiology
• Detection of plasma cell disorders by mass spectrometry: A comprehensive review of 19,523 cases.
  Mayo Clinic Proceedings
• CSF kappa free light chains: Cutoff validation for diagnosing multiple sclerosis.
  Mayo Clinic Proceedings

Chantell Canfield

Chantell Canfield is a web content coordinator for Mayo Clinic Laboratories. She began working for Mayo Clinic in 2021.