Mayo Clinic Laboratory and pathology research roundup: March 1

By Chantell Canfield • March 1, 2022

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The research roundup provides an overview of the past week’s research from Mayo Clinic Laboratories consultants, including featured abstracts and a complete list of published studies and reviews.

Featured Abstract

Phase II randomized trial of transoral surgery and low-dose intensity modulated radiation therapy in resectable p16+ locally advanced oropharynx cancer: An ECOG-ACRIN cancer research group trial (E3311).

Definitive or postoperative chemoradiation (CRT) is curative for human papillomavirus-associated (HPV+) oropharynx cancer (OPC) but induces significant toxicity. As a deintensification strategy, we studied primary transoral surgery (TOS) and reduced postoperative radiation therapy (RT) in intermediate-risk HPV+ OPC.

Read more.

Published to PubMed This Week

• Addition of navitoclax to ongoing ruxolitinib therapy for patients with Myelofibrosis with progression or suboptimal response: Phase II safety and efficacy.
  Journal of Clinical Oncology
• Breast cancer screening strategies for women with ATM, CHEK2, and PALB2 pathogenic variants: A comparative modeling analysis.
  JAMA Oncology
• Enhancer retargeting of CDX2 and UBTF::ATXN7L3 define a subtype of high-risk B-progenitor acute lymphoblastic leukemia.
  Blood
• Treatment of pouchitis, Crohn's disease, cuffitis, and other inflammatory disorders of the pouch: consensus guidelines from the international Ileal pouch consortium.
  The Lancet: Gastroenerology and Hepatology
• The 2021 WHO classification of tumors of the thymus and mediastinum: What is new in thymic epithelial, germ cell, and mesenchymal tumors?
  Journal of Thorac Oncology
• A clinically compatible drug-screening platform based on organotypic cultures identifies vulnerabilities to prevent and treat brain metastasis.
  EMBO Molecular Medicine
• High-dimensional and single-cell transcriptome analysis of the tumor microenvironment in angioimmunoblastic T cell lymphoma (AITL).
  Leukemia
• Polygenic risk score and risk of monoclonal B-cell lymphocytosis in caucasians and risk of chronic lymphocytic leukemia (CLL) in African Americans.
  Leukemia
• A simple additive staging system for newly diagnosed multiple myeloma.
  Blood Cancer Journal
• European LeukemiaNet-defined primary refractory acute myeloid leukemia: the value of allogeneic hematopoietic stem cell transplant and overall response.
  Blood Cancer Journal

Chantell Canfield

Chantell Canfield is a web content coordinator for Mayo Clinic Laboratories. She began working for Mayo Clinic in 2021.