Mayo Clinic Laboratory and pathology research roundup: March 29
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The research roundup provides an overview of the past week’s research from Mayo Clinic Laboratories consultants, including featured abstracts and a complete list of published studies and reviews.
Featured Abstract
Preclinical modeling in glioblastoma patient-derived xenograft (GBM PDX) xenografts to guide clinical development of lisavanbulin-a novel tumor checkpoint controller targeting microtubules.
We report a medium-throughput drug-screening platform (METPlatform) based on organotypic cultures that allows to evaluate inhibitors against metastases growing in situ. By applying this approach to the unmet clinical need of brain metastasis, we identified several vulnerabilities. Among them, a blood-brain barrier permeable HSP90 inhibitor showed high potency against mouse and human brain metastases at clinically relevant stages of the disease, including a novel model of local relapse after neurosurgery. Furthermore, in situ proteomic analysis applied to metastases treated with the chaperone inhibitor uncovered a novel molecular program in brain metastasis, which includes biomarkers of poor prognosis and actionable mechanisms of resistance. Our work validates METPlatform as a potent resource for metastasis research integrating drug-screening and unbiased omic approaches that is compatible with human samples. Thus, this clinically relevant strategy is aimed to personalize the management of metastatic disease in the brain and elsewhere.
Published to PubMed This Week
- Reimagining learning spaces of the future: An interprofessional, virtual workshop utilizing rapid idea generation and lean startup methodologies.
MedEdPortal - Exerkines in health, resilience and disease.
Nature Reviews: Endocrinology - Revisiting the definition of perioperative myocardial infarction after coronary artery bypass grafting.
European Heart Journal - Dynamics of plasmid-mediated niche invasion, immunity to invasion, and pheromone-inducible conjugation in the murine gastrointestinal tract.
Nature Communications - Cancer and immune-mediated necrotizing myopathy: A longitudinal referral case-controlled outcomes evaluation.
Rheumatology - Mass-Fix better predicts for PFS and OS than standard methods among multiple myeloma patients participating on the STAMINA trial (BMT CTN 0702 /07LT).
Blood Cancer Journal - Isolated anemia in patients with large granular lymphocytic leukemia (LGLL).
Blood Cancer Journal - Myelodysplastic/myeloproliferative neoplasms with ring sideroblasts and thrombocytosis (MDS/MPN-RS-T): Mayo-Moffitt collaborative study of 158 patients.
Blood Cancer Journal - Cytogenetic abnormalities in essential thrombocythemia: Clinical and molecular correlates and prognostic relevance in 809 informative cases.
Blood Cancer Journal - Real-world experience with luspatercept and predictors of response in myelodysplastic syndromes with ring sideroblasts.
American Journal of Hematology
