Mayo Clinic Laboratory and pathology research roundup: August 16
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The research roundup provides an overview of the past week’s research from Mayo Clinic Laboratories consultants, including featured abstracts and a complete list of published studies and reviews.
Featured Abstract
Identification of caveolae-associated protein 4 autoantibodies as a biomarker of immune-mediated rippling muscle disease in adults
Immune-mediated rippling muscle disease (iRMD) is a rare myopathy characterized by wavelike muscle contractions (rippling) and percussion- or stretch-induced muscle mounding. A serological biomarker of this disease is lacking. The findings indicate that cavin-4 IgG may be the first specific serological autoantibody biomarker identified in iRMD. Depletion of cavin-4 expression in muscle biopsies of patients with iRMD suggests the potential role of this autoantigen in disease pathogenesis.
Published to PubMed This Week
- Factors associated with physical activity levels in patients with breast cancer
The oncologist - How do I warm HPC(A) products to maximize cell viability in the setting of cold agglutinin disease?
Transfusion - The relationship between wild-type transthyretin amyloid load and ligamentum flavum thickness in lumbar stenosis patients.
World neurosurgery - In special coagulation, think horses not zebras: a clotted sample from a patient with congenital disorder of glycosylation
International journal of laboratory hematology - Molecular testing for diagnosis of early Lyme disease
American journal of clinical pathology - Therapeutic drug monitoring and dosage adjustments of immunosuppressive drugs when combined with nirmatrelvir/ritonavir in patients with COVID-19
Therapeutic drug monitoring - Targeted versus shotgun metagenomic sequencing-based detection of microorganisms in sonicate fluid for periprosthetic joint infection diagnosis
Clinical infectious diseases : an official publication of the Infectious Diseases Society of America - Machine learning-based fragment selection improves the performance of qualitative PRM assays
Journal of proteome research - An update on laboratory-based diagnostic biomarkers for multiple sclerosis and beyond
Clinical chemistry - Abnormal CD13/HLA-DR expression pattern on myeloblasts predicts development of myeloid neoplasia in patients with clonal cytopenia of undetermined significance
American journal of clinical pathology - Deepening responses post upfront ASCT in newly diagnosed multiple myeloma in the era of novel agent induction therapy
Transplantation and cellular therapy - Immunohistochemical approach to genetic subtyping of anaplastic large cell lymphoma
The American journal of surgical pathology - Latiglutenase protects the mucosa and attenuates symptom severity in patients with celiac disease exposed to a gluten challenge
Gastroenterology - Into the future: a pilot study combining imaging with molecular profiling to predict resectability in ovarian cancer
Gynecologic oncology - Lung allograft standardized histological analysis (LASHA) template: a research consensus proposal
The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation - Risk, prevalence, and progression of glaucoma in eyes with age-related macular degeneration treated with intravitreal anti-VEGF injections
American journal of ophthalmology - Histologic evaluation in the diagnosis and management of celiac disease: practical challenges, current best practice recommendations and beyond
Human pathology - Anaplastic thyroid carcinoma, squamous cell carcinoma pattern
Mayo Clinic proceedings - Flow cytometry for B-cell subset analysis in immunodeficiencies
Journal of immunological methods - An enhanced ceramide-based approach for primary prevention of atherosclerotic events
European heart journal open - Cross talk between lysine methyltransferase Smyd2 and TGF-β-Smad3 signaling promotes renal fibrosis in autosomal dominant polycystic kidney disease
American journal of physiology. Renal physiology - Radiation-associated angiosarcoma of the breast with initial presentation as non-mass enhancement on MRI
Radiology case reports - Immunohistochemical expression of renin & GATA3 help distinguish juxtaglomerular cell tumors from renal glomus tumors
Human pathology - Identification of two genetic loci associated with leukopenia after chemotherapy in patients with breast cancer
Clinical cancer research : an official journal of the American Association for Cancer Research
