Mayo Clinic Laboratory and pathology research roundup: August 23

By Samantha Rossi • August 23, 2022

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The research roundup provides an overview of the past week’s research from Mayo Clinic Laboratories consultants, including featured abstracts and a complete list of published studies and reviews.

Featured Abstract

High-sensitivity cardiac troponin and the 2021 AHA/ACC/ASE/CHEST/SAEM/SCCT/SCMR guidelines for the evaluation and diagnosis of acute chest pain

The 2021 American Heart Association/American College of Cardiology/American Society of Echocardiography/American College of Chest Physicians/Society for Academic Emergency Medicine/Society of Cardiovascular Computed Tomography/Society for Cardiovascular Magnetic Resonance guidelines for the evaluation and diagnosis of acute chest pain make important recommendations that include the recognition of high-sensitivity cardiac troponin (hs-cTn) as the preferred biomarker, endorsement of 99th percentile upper reference limits to define myocardial injury, and the use of clinical decision pathways, as well as acknowledgment of the uniqueness of women and other patient subsets.

Read more.

Published to PubMed This Week

• PFKFB3 regulates cancer stemness through the hippo pathway in small cell lung carcinoma
  Oncogene
• The effect of diabetes-associated variation in TCF7L2 on postprandial glucose metabolism when glucagon and insulin concentrations are matched
  Metabolic syndrome and related disorders
• Translational significance of CDKN2A/B homozygous deletion in IDH-mutant astrocytoma
  Neuro-oncology
• Progression and survival of monoclonal B-cell lymphocytosis (MBL): a screening study of 10,139 individuals
  Blood
• Clinical practice guidelines from the association for the advancement of blood and biotherapies (AABB): COVID-19 convalescent plasma
  Annals of internal medicine
• Proteomic identification and clinicopathologic characterization of splenic amyloidosis
  The American journal of surgical pathology
• Problems and solutions: a special issue of gastrointestinal, pancreatic, and liver pathology
  Human pathology
• Clinicopathologic and proteomic characteristics of intratubular cytoplasmic AL amyloidosis
  Kidney international
• Ultra-large von Willebrand factor and platelets: missing links to the pathogenesis of aortic valve stenosis?
  Basic to translational science
• Lenalidomide therapy for primary myelodysplastic syndromes with isolated del(5q): determinants of response and survival in a real-world setting
  American journal of hematology
• Plasma exchange in the intensive care unit: a narrative review
  Intensive care medicine
• Association of tumor-infiltrating lymphocytes (TILs) with survival depends on primary tumor sidedness in stage III colon cancers (NCCTG N0147) [alliance]
  Annals of oncology : official journal of the European Society for Medical Oncology
• BARX2/FOXA1/HK2 axis promotes lung adenocarcinoma progression and energy metabolism reprogramming
  Translational lung cancer research
• Immunoscore is prognostic in low-risk and high-risk stage III colon carcinomas treated with adjuvant infusional fluorouracil, leucovorin, and oxaliplatin in a phase III trial
  JCO precision oncology
• Association of plasma biomarkers of amyloid and neurodegeneration with cerebrovascular disease and Alzheimer's disease
  Neurobiology of aging
  

Samantha Rossi

Samantha Rossi is a Digital Marketing Manager at Mayo Clinic Laboratories. She supports marketing strategies for product management and specialty testing. Samantha has worked at Mayo Clinic since 2019.