Mayo Clinic Laboratory and pathology research roundup: September 13

By Samantha Rossi • September 13, 2022

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The research roundup provides an overview of the past week’s research from Mayo Clinic Laboratories consultants, including featured abstracts and a complete list of published studies and reviews.

Featured Abstract

A simple score to identify increased risk of transthyretin amyloid cardiomyopathy in heart failure with preserved ejection fraction

Transthyretin amyloid cardiomyopathy (ATTR-CM) is a form of heart failure (HF) with preserved ejection fraction (HFpEF). Technetium Tc 99m pyrophosphate scintigraphy (PYP) enables ATTR-CM diagnosis. It is unclear which patients with HFpEF have sufficient risk of ATTR-CM to warrant PYP. To derive and validate a simple ATTR-CM score to predict increased risk of ATTR-CM in patients with HFpEF. Retrospective cohort study of 666 patients with HF (ejection fraction ≥ 40%) and suspected ATTR-CM referred for PYP at Mayo Clinic, Rochester, Minnesota, from May 10, 2013, through August 31, 2020. These data were analyzed September 2020 through December 2020. 

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Published to PubMed This Week

• Plexiform fibrohistiocytic tumor: a clinicopathological and immunohistochemical study of 39 tumors, with evidence for a CSF1-producing "null cell" population
  Virchows Archiv : an international journal of pathology
• Human leukocyte antigen (HLA) testing in pharmacogenomics
  Methods in molecular biology (Clifton, N.J.)
• Updates on eosinophilic disorders
  Virchows Archiv : an international journal of pathology
• Granulomatosis with polyangiitis presenting as obstructive uropathy and vasculitic myopathy
  Rheumatology (Oxford, England)
• Optimum differentiation of frontotemporal lobar degeneration from Alzheimer disease achieved with cross-sectional tau positron emission tomography
  Annals of neurology
• The prevalence and clinical outcomes of microangiopathic hemolytic anemia in patients with biopsy proven renal thrombotic microangiopathy
  American journal of hematology
• Clinical impact of cardiac fibromas
  The American journal of cardiology
• Geographic distribution of otolaryngology training programs and potential opportunities for strategic program growth
  The Laryngoscope
• Septin-5 and -7-IgGs: neurologic, serologic, and pathophysiologic characteristics
  Annals of neurology
• Comparison of two free light chain assays: performance of the involved free light chain ratio and implications for diagnosis of multiple myeloma
  Blood cancer journal
• Diagnostic approaches and future directions in Burkitt lymphoma and high-grade B-cell lymphoma
  Virchows Archiv : an international journal of pathology
• Momelotinib for myelofibrosis: 12-year survival data and retrospective comparison to ruxolitinib
  American journal of hematology
• Anastomosing Hemangioma
  Mayo Clinic proceedings
• Clinical outcomes in patients with chronic lymphocytic leukemia with disease progression on ibrutinib
  Blood cancer journal
  

Samantha Rossi

Samantha Rossi is a Digital Marketing Manager at Mayo Clinic Laboratories. She supports marketing strategies for product management and specialty testing. Samantha has worked at Mayo Clinic since 2019.