Mayo Clinic Laboratory and pathology research roundup: October 4

By Samantha Rossi • October 4, 2022

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The research roundup provides an overview of the past week’s research from Mayo Clinic Laboratories consultants, including featured abstracts and a complete list of published studies and reviews.

Featured Abstract

Tumor microenvironment CD14⁺ cells correlate with poor overall survival in patients with early-stage lung adenocarcinoma

Patients with early-stage lung adenocarcinoma have a high risk of recurrent or metastatic disease despite undergoing curative intent therapy. We hypothesized that increased CD14⁺ cells within the tumor microenvironment (TME) could stratify patient outcomes. Immunohistochemistry for CD14 was performed on 189 specimens from patients with lung adenocarcinoma who underwent curative intent surgery. Outcomes and associations with clinical and pathologic variables were determined.

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Published to PubMed This Week

• Acute symptomatic seizures secondary to myelin oligodendrocyte glycoprotein antibody-associated disease.
  Epilepsia
• Activity of a hypochlorous acid-producing electrochemical-bandage as assessed with a porcine explant biofilm model
  Biotechnology and bioengineering
• Increasing tissue requirements in lymphoma trials may exclude patients with high risk disease or worse prognosis
  Blood advances
• A 92 protein inflammation panel performed on sonicate fluid differentiates periprosthetic joint infection from non-infectious causes of arthroplasty failure
  Scientific reports
• Predictors of histologic response to dietary therapy in eosinophilic oesophagitis
  Alimentary pharmacology & therapeutics
• ITMIG 2021 tumor board: a case of a 37-year-old man with TNM stage IVA thymoma
  Mediastinum (Hong Kong, China)
• Vaccine-boosted convalescent plasma therapy for patients with immunosuppression and COVID-19
  Blood advances
• Computational tumor stroma reaction evaluation led to novel prognosis-associated fibrosis and molecular signature discoveries in high-grade serous ovarian carcinoma
  Frontiers in medicine, 9
• Imaging of the bulbourethral (Cowper) gland: abnormalities and differential diagnosis.
  Radiographics : a review publication of the Radiological Society of North America, Inc
• Pathogen detection in infective endocarditis using targeted metagenomics on whole blood and plasma: a prospective pilot study
  Journal of clinical microbiology, 60
• AMPK: The key to ischemia-reperfusion injury
  Journal of cellular physiology
• Molecular profile changes in castrate resistant prostate cancer patients pre and post-abiraterone/prednisone treatment
  Molecular cancer research : MCR
• Recent trends in Medicare utilization and reimbursement for lumbar fusion procedures: 2000-2019
  World neurosurgery

Samantha Rossi

Samantha Rossi is a Digital Marketing Manager at Mayo Clinic Laboratories. She supports marketing strategies for product management and specialty testing. Samantha has worked at Mayo Clinic since 2019.