Mayo Clinic Laboratory and pathology research roundup: October 11

By Samantha Rossi • October 11, 2022

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The research roundup provides an overview of the past week’s research from Mayo Clinic Laboratories consultants, including featured abstracts and a complete list of published studies and reviews.

Featured Abstract

Transcriptomic analysis of cirrhosis-like hepatocellular carcinoma reveals distinct molecular characteristics and pathologic staging implications

Cirrhosis-like hepatocellular carcinoma (CL-HCC) is a rare hepatocellular malignancy characterized by multiple tumor nodules that clinically, radiologically, macroscopically, and microscopically mimic cirrhosis. We aimed to elucidate the molecular biology of CL-HCC and determine tumor nodule clonality. We performed RNA sequencing on formalin-fixed, paraffin-embedded tissue from confirmed CL-HCC cases (n = 6), along with corresponding non-neoplastic hepatic tissue (n = 4) when available. Histologically, CL-HCC displayed innumerable nodules and extensive vascular invasion. Intratumoral nodule comparison indicated that the multiple nodules were all clonally related, not independent primaries.

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Published to PubMed This Week

• Daunorubicin-60 versus daunorubicin-90 versus idarubicin-12 for induction chemotherapy in acute myeloid leukemia: a retrospective analysis of the Mayo Clinic experience
  Haematologica
• Factors associated with physical activity levels in patients with breast cancer
  The oncologist
• STAT3 is a biologically relevant therapeutic target in H3K27M-mutant diffuse midline glioma
  Neuro-oncology, 24
• Lung allograft standardized histological analysis (LASHA) template: A research consensus proposal
  The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation, 41
• A diagnostic approach to paratesticular lesions with tubulopapillary architecture: a series of 16 serous borderline tumors/low-grade serous carcinoma and 14 well-differentiated papillary mesothelial tumors and mesothelioma
  Human pathology, 128
• Immunohistochemical expression of renin and GATA3 help distinguish juxtaglomerular cell tumors from renal glomus tumors
  Human pathology, 128
• Transmission electron microscopy on a case of cyclospora cayetanensis infection from an immune-competent case confirms and extends prior detailed descriptions of its notably small endogenous stage
  Parasitology, 149
• Autoimmune manifestations in STAG2-mutated myeloid neoplasms
  Annals of hematology
• PFKFB3 works on the FAK-STAT3-SOX2 axis to regulate the stemness in MPM
  British journal of cancer, 127
• A 92 protein inflammation panel performed on sonicate fluid differentiates periprosthetic joint infection from non-infectious causes of arthroplasty failure
  Scientific reports, 12
• Von Willebrand factor multimer analysis and classification: a comprehensive review and updates
  Seminars in thrombosis and hemostasis

Samantha Rossi

Samantha Rossi is a Digital Marketing Manager at Mayo Clinic Laboratories. She supports marketing strategies for product management and specialty testing. Samantha has worked at Mayo Clinic since 2019.