Mayo Clinic Laboratory and pathology research roundup: October 11
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The research roundup provides an overview of the past week’s research from Mayo Clinic Laboratories consultants, including featured abstracts and a complete list of published studies and reviews.
Featured Abstract
Transcriptomic analysis of cirrhosis-like hepatocellular carcinoma reveals distinct molecular characteristics and pathologic staging implications
Cirrhosis-like hepatocellular carcinoma (CL-HCC) is a rare hepatocellular malignancy characterized by multiple tumor nodules that clinically, radiologically, macroscopically, and microscopically mimic cirrhosis. We aimed to elucidate the molecular biology of CL-HCC and determine tumor nodule clonality. We performed RNA sequencing on formalin-fixed, paraffin-embedded tissue from confirmed CL-HCC cases (n = 6), along with corresponding non-neoplastic hepatic tissue (n = 4) when available. Histologically, CL-HCC displayed innumerable nodules and extensive vascular invasion. Intratumoral nodule comparison indicated that the multiple nodules were all clonally related, not independent primaries.
Published to PubMed This Week
- Daunorubicin-60 versus daunorubicin-90 versus idarubicin-12 for induction chemotherapy in acute myeloid leukemia: a retrospective analysis of the Mayo Clinic experience
Haematologica - Factors associated with physical activity levels in patients with breast cancer
The oncologist - STAT3 is a biologically relevant therapeutic target in H3K27M-mutant diffuse midline glioma
Neuro-oncology, 24 - Lung allograft standardized histological analysis (LASHA) template: A research consensus proposal
The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation, 41 - A diagnostic approach to paratesticular lesions with tubulopapillary architecture: a series of 16 serous borderline tumors/low-grade serous carcinoma and 14 well-differentiated papillary mesothelial tumors and mesothelioma
Human pathology, 128 - Immunohistochemical expression of renin and GATA3 help distinguish juxtaglomerular cell tumors from renal glomus tumors
Human pathology, 128 - Transmission electron microscopy on a case of cyclospora cayetanensis infection from an immune-competent case confirms and extends prior detailed descriptions of its notably small endogenous stage
Parasitology, 149 - Autoimmune manifestations in STAG2-mutated myeloid neoplasms
Annals of hematology - PFKFB3 works on the FAK-STAT3-SOX2 axis to regulate the stemness in MPM
British journal of cancer, 127 - A 92 protein inflammation panel performed on sonicate fluid differentiates periprosthetic joint infection from non-infectious causes of arthroplasty failure
Scientific reports, 12 - Von Willebrand factor multimer analysis and classification: a comprehensive review and updates
Seminars in thrombosis and hemostasis
