Mayo Clinic Laboratory and pathology research roundup: October 25

By Samantha Rossi • October 25, 2022

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The research roundup provides an overview of the past week’s research from Mayo Clinic Laboratories consultants, including featured abstracts and a complete list of published studies and reviews.

Featured Abstract

Automated scoring of total inflammation in renal allograft biopsies

Computer-assisted scoring is gaining prominence in the evaluation of renal histology; however, much of the focus has been on identifying larger objects such as glomeruli. Total inflammation impacts graft outcome, and its quantification requires tools to identify objects at the cellular level or smaller. Automated scoring of inflammation showed a high correlation with Banff scoring. Digital image analysis provides a powerful tool for analysis of renal pathology, not only because it is reproducible and can be automated, but also because it provides much more granular data for studies.

Read more.

Published to PubMed This Week

• Natural language processing for identification of hypertrophic cardiomyopathy patients from cardiac magnetic resonance reports
  BMC medical informatics and decision making
• Malignant rhabdoid tumor: cyto-histologic correlation and immunohistochemical characterization of a rare pediatric malignancy and its differential diagnoses
  Annals of diagnostic pathology
• Incorporation of genetic studies in the kidney transplant evaluation clinic: the value of a multidisciplinary approach
  Transplantation
• Culture media composition influences patient-derived organoids ability to predict therapeutic response in gastrointestinal cancers
  JCI insight
• The many faces of globular glial tauopathy: a clinical and imaging study
  European journal of neurology
• Progression and survival of MBL: a screening study of 10 139 individuals
  Blood, 140
• A simple score to identify increased risk of transthyretin amyloid cardiomyopathy in heart failure with preserved ejection fraction
  JAMA cardiology, 7
• Diagnostic and therapeutic strategy in anaplastic (malignant) meningioma, CNS WHO grade 3
  Cancers, 14
• PTEN loss promotes Warburg effect and prostate cancer cell growth by inducing FBP1 degradation
  Frontiers in oncology
• Prognostic value of diffuse crescentic lesions in fibrillary glomerulonephritis
  American journal of kidney diseases : the official journal of the National Kidney Foundation
• Underestimation of aortic stenosis severity by doppler mean gradient during atrial fibrillation: insights from aortic valve weight
  Journal of the American Society of Echocardiography : official publication of the American Society of Echocardiography

Samantha Rossi

Samantha Rossi is a Digital Marketing Manager at Mayo Clinic Laboratories. She supports marketing strategies for product management and specialty testing. Samantha has worked at Mayo Clinic since 2019.