Mayo Clinic Laboratory and pathology research roundup: November 1
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The research roundup provides an overview of the past week’s research from Mayo Clinic Laboratories consultants, including featured abstracts and a complete list of published studies and reviews.
Featured Abstract
Alliance A071401: phase II trial of focal adhesion kinase inhibition in meningiomas with somatic NF2 mutations
Patients with progressive or recurrent meningiomas have limited systemic therapy options. Focal adhesion kinase (FAK) inhibition has a synthetic lethal relationship with NF2 loss. Eligible patients whose tumors screened positively for NF2 mutations were treated with GSK2256098, 750 mg orally twice daily, until progressive disease. Of 322 patients screened for all mutation cohorts of the study, 36 eligible and evaluable patients with NF2 mutations were enrolled and treated: 12 grade 1 and 24 grade 2/3 patients. GSK2256098 was well tolerated and resulted in an improved PFS6 rate in patients with recurrent or progressive NF2-mutated meningiomas, compared with historical controls.
Published to PubMed This Week
- Risk, prevalence, and progression of glaucoma in eyes with age-related macular degeneration treated with intravitreal anti-vascular endothelial growth factor injections
American journal of ophthalmology, 243 - Rates of asymptomatic COVID-19 infection and associated factors in Olmsted County, MN in the pre-vaccination era
Mayo Clinic proceedings. Innovations, quality & outcomes - Histoplasma capsulatum complement fixation and immunodiffusion assay sensitivity in culture-confirmed cases of histoplasmosis: a 10-year retrospective review (2011 to 2020)
Journal of clinical microbiology, 60 - Development and technical validation of an artificial intelligence model for quantitative analysis of histopathologic features of eosinophilic esophagitis
Journal of pathology informatics, 13 - G9a modulates lipid metabolism in CD4 T cells to regulate intestinal inflammation
Gastroenterology - mTORC2 contributes to systemic autoimmunity
Immunology - Retinoblastoma protein as an intrinsic BRD4 inhibitor modulates small molecule BET inhibitor sensitivity in cancer
Nature communications - Clinical laboratory informatics and analytics: challenges and opportunities
Clinical chemistry - The effect of burosumab on intact and C-terminal FGF23 measurements
Clinical endocrinology - Exploring gene expression profiles in primary central nervous system vasculitis
Annals of neurology - Contemporary updates in urologic pathology: a special issue of renal, urinary tract, prostate, penile & testicular pathology
Human pathology - Clinically adjudicated reference standards for evaluation of infectious diseases diagnostics
Clinical infectious diseases : an official publication of the Infectious Diseases Society of America - Natural language processing for identification of hypertrophic cardiomyopathy patients from cardiac magnetic resonance reports
BMC medical informatics and decision making, 22
