Mayo Clinic Laboratory and pathology research roundup: November 15

By Samantha Rossi • November 15, 2022

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The research roundup provides an overview of the past week’s research from Mayo Clinic Laboratories consultants, including featured abstracts and a complete list of published studies and reviews.

Featured Abstract

Renin production by juxtaglomerular cell tumors and clear cell renal cell carcinoma and the role of angiotensin signaling inhibitors

To profile juxtaglomerular cell tumors (JXG) and histologic mimics by analyzing renin expression; to identify non-JXG renin-producing tumors in The Cancer Genome Atlas (TCGA) data sets; and to define the prevalence of hypertension (HTN) and patient outcomes with angiotensin signaling inhibitor (ASI) use in tumors of interest. Thirteen JXGs and 10 glomus tumors (GTs), a histologic mimic, were evaluated for clinicopathologic features; TCGA data were analyzed to identify non-JXG renin-overexpressing tumors. We found an association between renin production and HTN in JXG compared with GT. Analysis of TCGA data found that a subset of CC-RCCs overexpress renin relative to 29 other tumor types.

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Published to PubMed This Week

• 1,3-β-D-glucan testing for nocardiosis in solid organ transplant recipients
  Transplant infectious disease : an official journal of the Transplantation Society
• Core genome multilocus sequence typing and antibiotic susceptibility prediction from whole-genome sequence data of multidrug-resistant pseudomonas aeruginosa isolates
  Mayo Clinic proceedings, 97
• Plexiform fibrohistiocytic tumor: a clinicopathological and immunohistochemical study of 39 tumors, with evidence for a CSF1-producing "null cell" population
  Virchows Archiv : an international journal of pathology, 481
• Oncocytic parathyroid adenoma
  Mayo Clinic proceedings, 97
• Pitfalls in diagnosing hypoglycemia due to exogenous insulin: validation and utility of an insulin analog assay
   Mayo Clinic proceedings, 97
• Impact of residents on hand surgery fellows' educational experience: a cross-sectional survey
  The Journal of hand surgery, 47
• Deepening responses after upfront autologous stem cell transplantation in patients with newly diagnosed multiple myeloma in the era of novel agent induction therapy
  Transplantation and cellular therapy, 28
• Single-nucleotide polymorphism array for histologically ambiguous melanocytic tumors
  The Journal of molecular diagnostics : JMD, 24
• Acute interstitial nephritis on positron-emission tomography-computed tomography imaging
  Kidney medicine, 4
• Autologous extracellular vesicles attenuate cardiac injury in experimental atherosclerotic renovascular disease more effectively than their parent mesenchymal stem/stromal cells
  Stem cell reviews and reports
• Co-mutational pattern of somatic GATA2-mutated myeloid neoplasms
  Annals of hematology
• Extranodal T- and NK-cell lymphomas
  Virchows Archiv : an international journal of pathology
• Implementation of high-sensitivity cardiac troponin assays in the United States
  Journal of the American College of Cardiology
• Identification of decreased butyrylcholinesterase in sudden infant death syndrome is, at best, a first step toward preventive screening
  Clinical chemistry
• Imaging of the bulbourethral (Cowper) gland: abnormalities and differential diagnosis
  Radiographics : a review publication of the Radiological Society of North America, Inc, 42
• Imaging features in the liver after stereotactic body radiation therapy
  Radiographics : a review publication of the Radiological Society of North America, Inc, 42
• H3 G34 mutation assessment for diffuse gliomas in adults: when would testing be most diagnostically useful?
  Journal of neuropathology and experimental neurology
• Pure (acute) erythroid leukemia: morphology, immunophenotype, cytogenetics, mutations, treatment details, and survival data among 41 Mayo Clinic cases
  Blood cancer journal, 12
• Light chain-only immunotactoid glomerulopathy: a case report
  American journal of kidney diseases : the official journal of the National Kidney Foundation
• Is there clinically relevant plasma interference with ELISA detection of APS antibodies? Reproducibility of real-world paired serum and plasma testing
  Thrombosis and haemostasis, 122

Samantha Rossi

Samantha Rossi is a Digital Marketing Manager at Mayo Clinic Laboratories. She supports marketing strategies for product management and specialty testing. Samantha has worked at Mayo Clinic since 2019.